DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4382 and CES2

DIOPT Version :10

Sequence 1:NP_609301.2 Gene:CG4382 / 34279 FlyBaseID:FBgn0032132 Length:580 Species:Drosophila melanogaster
Sequence 2:NP_003860.3 Gene:CES2 / 8824 HGNCID:1864 Length:559 Species:Homo sapiens


Alignment Length:613 Identity:168/613 - (27%)
Similarity:247/613 - (40%) Gaps:131/613 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 CGFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGTILPSQSGRN--FY 67
            ||.:||   |..||..|    .|.|               :.||..|::.|::: ...|.|  ..
Human    15 CGLLLL---LVRGQGQD----SASP---------------IRTTHTGQVLGSLV-HVKGANAGVQ 56

  Fly    68 AFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ--------------LGLVSGDVSE 118
            .|.|||:||||:..|||.||||.|.|....|.|.....|.|              :...|..:||
Human    57 TFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSE 121

  Fly   119 DCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGS 183
            |||.::|||   |:.|......||:|:||.|..  :.|.:..:.|........:|:|...||||.
Human   122 DCLYLSIYT---PAHSHEGSNLPVMVWIHGGAL--VFGMASLYDGSMLAALENVVVVIIQYRLGV 181

  Fly   184 LGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGL 248
            |||.:||.:.|.||.|..|||..||||:.:|:.|||:|..:|:.|..||..:|:..:|||:|:||
Human   182 LGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGL 246

  Fly   249 FHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTENVTEMMDCLKGKHYLEFANTLPKMFEFD 313
            ||.||:.||.......:......::|..|.|..|...:...::.||:||               .
Human   247 FHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGK---------------S 296

  Fly   314 RNNPLILWKPV-IEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEF---VGPALSI----- 369
            :...|.:.||. :.|......||...|.....:.||..||.|.|:..:||   :...:.|     
Human   297 KEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQK 361

  Fly   370 ----------LQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHYFPDKLIDANRSLE 424
                      ||....|..|...|..|                    ||..|..|.  ...::|:
Human   362 EMDREASQAALQKMLTLLMLPPTFGDL--------------------LREEYIGDN--GDPQTLQ 404

  Fly   425 A-LSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSYQGARSHIYYPEDAPYGVVHHDDLMYLFVE 488
            | ...:.:|::......:..|.......||:|.|.:|.:......|   |:....|.|.:     
Human   405 AQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRP---PHMKADHGDEL----- 461

  Fly   489 PSISR--------MFTEDDDEFRMVDIMVRMFSAFAYKGDPN---KPTDLALRDIRWRPFSFKKR 542
            |.:.|        .|||::::....  |::.::.||..|:||   .|        .| |...::.
Human   462 PFVFRSFFGGNYIKFTEEEEQLSRK--MMKYWANFARNGNPNGEGLP--------HW-PLFDQEE 515

  Fly   543 YYLDIGKHITLEENLNAENYEIWKRLFP 570
            .||.:.....:...|.|...:.||:..|
Human   516 QYLQLNLQPAVGRALKAHRLQFWKKALP 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4382NP_609301.2 COesterase 42..565 CDD:395084 155/569 (27%)
CES2NP_003860.3 COesterase 30..538 CDD:395084 157/584 (27%)
Prevents secretion from ER. /evidence=ECO:0000255 556..559
Blue background indicates that the domain is not in the aligned region.

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