DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and Ces2f

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001073334.2	Gene:	Ces2f / 71903	MGIID:	1919153	Length:	561	Species:	Mus musculus

Alignment Length:	589	Identity:	169/589 - (28%)
Similarity:	257/589 - (43%)	Gaps:	81/589 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CGFVLLLC---GLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGT---ILPSQSG 63
            ||.::||.   ||        |.|:|.|               :..|..|::||.   :...::|
Mouse    15 CGLLVLLLHVKGL--------DSSEASP---------------IRNTHTGQVRGKFVHLTDIKAG 56

  Fly    64 RNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDAT--------------FDGPKCPQLGLVSG 114
            .  :.|.|||:|||||..|||.|||..|.|....|.|              .:|.|..::.|...
Mouse    57 A--HNFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSQPAMCLQNDDIVNLEGLKIIKMILPPF 119

  Fly   115 DVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNY 179
            .:|||||.:||||   |:.:|.....||:|::|.||.  ::|.:..:.|........:|:|...|
Mouse   120 SMSEDCLYLNIYT---PAHAQEGSNLPVMVWLHGGGL--VAGMASMYDGSVLAATEDVVVVVTQY 179

  Fly   180 RLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPM 244
            |||..||.:||..:|.||.|..||...|.||:.:|:.|||:|.|:||.|..||..:|:.|::||:
Mouse   180 RLGIPGFYSTGDEQARGNWGFLDQTAALHWVQQNIANFGGNPDSVTLFGQSAGGTSVSFHVLSPV 244

  Fly   245 SRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTENVTEMMDCLKGKHYLEFANTLPKM 309
            |:||||:||:.||.......:||....:.||.|.|..|.|.|...::.||:||...|.. .:.|.
Mouse   245 SQGLFHRAIMESGVALLPTIIPDSPEMIFTKVANLSGCETSNSEALVRCLRGKSEAEIL-AMSKA 308

  Fly   310 FEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEFVGPALSILQ-SP 373
            |.|             .|.....:||...|.:...:.||..||.|.|:..||:......|.: |.
Mouse   309 FRF-------------MPAVVDGKFLPRHPKKLLASADFHPVPSIIGVNNDEYGWIIPKIFKFSQ 360

  Fly   374 TLLSALNENFESLAPVFF--MYNTSDARACNISQELRNHYFPDKLIDANRSLEALSNLYSDALTG 436
            |:......|.:::..:..  |...|:.....|.:.||:...|..|   ......:...:...:..
Mouse   361 TIRKINRNNLKAIMKITTEQMMLPSECGDLLIEEYLRDTEDPWTL---QMQFREMIGDFLIIIPA 422

  Fly   437 FGIHRFVHLAARSTKVYYYRFSYQGARSHIYYPEDAPYGVVHHDDLMYLFVEPSISRMFTEDDDE 501
            ..:.||....|   .||:|.|.::.:....:.|....  ..|.|:|..:|........|:...:|
Mouse   423 LQVARFQRSHA---PVYFYEFQHRSSLLKYFRPWHVK--ADHGDELYLIFGSFFWGLKFSFTAEE 482

  Fly   502 FRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRPFSFKKRYYLDIGKHITLEENLNAENYEIWK 566
            ..:...|::.::.||..|:||.      .|:.:.|.|.:...||.:..|.::...|.|.....|.
Mouse   483 KLLSRKMMKYWANFARYGNPNS------EDLPYWPASNQDDLYLQLDIHPSVGHALKARRLPFWT 541

  Fly   567 RLFP 570
            :..|
Mouse   542 KTLP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	157/543 (29%)
Ces2f	NP_001073334.2	COesterase	32..540	CDD:395084	159/557 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890