Protein Alignment CG4382 and TG

DIOPT Version :10

• Sequence 1: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_003226.4
• Gene: TG / 7038
• HGNCID: 11764
• Length: 2768
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 151/576 - (26%)
• Similarity: 243/576 - (42%)
• Gaps: 133/576 - (23%)

  Fly    51 GKIRGTILPSQSGRNFY---AFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQLGL- 111
            |::.|.....|.|.::.   .|.|:|||.||:...|||.|||: .|..:.||:.....|.|.|.
Human  2207 GRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPL-NWTGSWDASKPRASCWQPGTR 2270

  Fly   112 --VSGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIH-------PGGFYSLSGQSKNFAGPQYF 167
              .|..||||||.:|::   :|....||.  .|:||.|       ..|:.::.|......|
Human  2271 TSTSPGVSEDCLYLNVF---IPQNVAPNA--SVLVFFHNTMDREESEGWPAIDGSFLAAVG---- 2326

  Fly   168 MNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAG 232
               .|::||.:||:|..|||::|:.|..||.||.|||..|.||:.||..|||||..::|.....|
Human  2327 ---NLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGG 2388

  Fly   233 AMAVTLHMVSPMSRG--LFHKAIVMSGAVTGQWSLPDHQMDVATKQATLL----HCHTENVTEMM 291
            |...::|:::..:..  ||.:|::|.|:.....::..|:.  |.:||..|    .|...:..|::
Human  2389 ADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHER--AQQQAIALAKEVSCPMSSSQEVV 2451

  Fly   292 DCLKGK--HYLEFANTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPII 354
            .||:.|  :.|..|.|  |:...  :.|...|.|||:     ..||.|.|.|:.:...:::|.::
Human  2452 SCLRQKPANVLNDAQT--KLLAV--SGPFHYWGPVID-----GHFLREPPARALKRSLWVEVDLL 2507

  Fly   355 TGMTKDE-FVGPALSILQSPTLLSALNENFE------SLAPVFF--MYNT-----SDARACNISQ 405
            .|.::|: .:..|.::.|           ||      |....|:  :.|:     ||||.    :
Human  2508 IGSSQDDGLINRAKAVKQ-----------FEESRGRTSSKTAFYQALQNSLGGEDSDARV----E 2557

  Fly   406 ELRNHYF-----PDKLIDANRSLEALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSYQGARSH 465
            .....|:     .|.....:|:||..:..|      |.|...:.:|:...|         .||.:
Human  2558 AAATWYYSLEHSTDDYASFSRALENATRDY------FIICPIIDMASAWAK---------RARGN 2607

  Fly   466 IYY---PEDAPYGVVHHDDL---------MYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYK 518
            ::.   ||:  ||   |..|         :.|...|:....|:.::....:.  :::.||.|...
Human  2608 VFMYHAPEN--YG---HGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLK--IMQYFSHFIRS 2665

  Fly   519 GDPNKPTDLALR----DIRWRPFSFKKRYYLDIGKHITLEENLNAENYEIWKRLFP 570
            |:||.|.:.:.:    ...|..|                ......|||:.:..|.|
Human  2666 GNPNYPYEFSRKVPTFATPWPDF----------------VPRAGGENYKEFSELLP 2705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	42..565	CDD:395084	149/569 (26%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:459665
		Thyroglobulin_1	662..724	CDD:459665
		TY	730..>776	CDD:469630
		TY	<892..922	CDD:469630
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:429604
		Type II. /evidence=ECO:0000269|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710	2188..2768		151/576 (26%)
		COesterase	2197..2718	CDD:395084	151/576 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2727..2768