DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and Ces1a

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001177304.1	Gene:	Ces1a / 679817	RGDID:	1583671	Length:	563	Species:	Rattus norvegicus

Alignment Length:	594	Identity:	173/594 - (29%)
Similarity:	255/594 - (42%)	Gaps:	118/594 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VITTALGKIRGTILPSQSGRNFYA-FRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ 108
            |:.|..||:.|..:..:......| |.|:|:||||:..|||.||:|.|.|....:||...|.|.|
  Rat    25 VVDTLQGKVLGKYISLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAESWSFVKNATSYPPMCSQ 89

  Fly   109 L---GLVSGDV------------SEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQS 158
            :   |.|..:|            |||||.:|||:   |::.....|.||:|::|.||.  |||.:
  Rat    90 ITGVGPVLSEVFTNQLENVPLEYSEDCLYLNIYS---PTDLTSKDRLPVMVWVHGGGL--LSGGA 149

  Fly   159 KNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSS 223
            ..|.|.....:.::|:|...||||..|||:||...:.||.|..|||..|:||:.:|..|||||:|
  Rat   150 STFDGLALSTHEKVVVVVIQYRLGIWGFLSTGDEHSRGNWGHFDQVAALQWVQNNIVNFGGDPNS 214

  Fly   224 ITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTENVT 288
            :||.|..||..:|::.::||:::.|||:||..||.........::....|.:.|....|......
  Rat   215 VTLFGESAGGESVSVLVLSPLTKNLFHRAISESGVALTPCLFRENTRLAAEQVAIATGCAATTSA 279

  Fly   289 EMMDCLKGKHYLEFANTLPKM--FEFDRNNPLILWKPVIEPDFGQER-------------FLVEE 338
            :::.||:.|...|...|..||  |..|.:              |..|             .|.:.
  Rat   280 DIVRCLREKTEEELLATTLKMKFFALDLH--------------GDPRESYPFLTTVIDGVLLPKA 330

  Fly   339 PIRSYQNDDFMKVPIITGMTKDEF-------VGPAL--SILQSPTLLSALNENFESLAPVFFMYN 394
            |.......:|..||.|.|:.|.||       :|..|  |.|...|..|.|.:::    |:
  Rat   331 PEEILSEKNFNTVPYIVGINKQEFGWFIPTMMGYPLSESKLDQKTATSLLWKSY----PL----- 386

  Fly   395 TSDARACNISQEL----RNHYF-----PDKLIDANRSLEALSNLYSDALTGFGIHRFV----HLA 446
                  .|||:||    ...|.     |||..|      ...::..|.|  |.:...:    |..
  Rat   387 ------TNISKELTPVATEKYLGGSDCPDKKKD------LFLDMMGDVL--FAVPSVIVARYHRD 437

  Fly   447 ARSTKVYYYRFSYQGARSHIYYPED-APYGVV--HHDDLMYLFVEPSISRMFTEDDDEFRMVDIM 508
            ||:| .|.|.|.|     |..:..| .|..|:  |.|::..::..|.:....:|  :|..:..:|
  Rat   438 ARAT-TYVYEFKY-----HPSFVSDMRPKTVIADHGDEVYSVWGTPFLKEGASE--EEINLSTMM 494

  Fly   509 VRMFSAFAYKGDPN---KPTDLALRDIRWRPFSFKKRYYLDIGKHITLEENLNAENYEIWKRLFP 570
            ::.:..||..|:||   .|        .|..:. :|..||.||..|...:.|..:....|..|..
  Rat   495 MKFWGNFARNGNPNGEGLP--------HWPEYD-EKESYLQIGTTIQQAQKLKYKEVAFWTGLRG 550

  Fly   571 LNWRRQTKE 579
            :.....|:|
  Rat   551 MEVEEATEE 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	169/578 (29%)
Ces1a	NP_001177304.1	COesterase	24..545	CDD:278561	169/578 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336534
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.900