DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and Ces5a

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001368779.1	Gene:	Ces5a / 67935	MGIID:	1915185	Length:	579	Species:	Mus musculus

Alignment Length:	565	Identity:	160/565 - (28%)
Similarity:	247/565 - (43%)	Gaps:	95/565 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TALGKIRG---TILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKC--- 106
            |.||.::|   |:|......|  .|.|||:|.||:..|||..|:|...|.:..:||.....|
Mouse    39 TKLGWVQGKQATVLGRLEPVN--VFLGIPFAAPPLGPLRFSKPQPPIPWDNLREATAYPNLCFQN 101

  Fly   107 ---------------PQLGLVSGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSG 156
                           |.||:     |||||.:|||.   |..:......||:|:|..|||.  :|
Mouse   102 LEWLFIYQNLLKVSYPILGM-----SEDCLYLNIYA---PCHANNGSSLPVMVWIPGGGFE--TG 156

  Fly   157 QSKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDP 221
            .:..|.|....:...:::||..||||..||..|..:.||||....||:..|.||:.:|..|||:|
Mouse   157 SASIFDGSALAVYEDVLVVTIQYRLGIFGFFTTQNQHAPGNWAFWDQLAALLWVRENIKYFGGNP 221

  Fly   222 SSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSG-AVTGQWSLPD----HQMDVATKQATLLH 281
            .|:|:.|..|||::::..::||:|..|||:||:.|| |:.......|    |.:.|.   |.:..
Mouse   222 DSVTIFGNSAGAISISSLILSPLSADLFHRAIMQSGVAIIPSLKSSDNDLKHDLQVV---ANVCD 283

  Fly   282 CHTENVTEMMDCLKGKHYLEFANTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQND 346
            |:..:...::.||:.|..||..:...|...|.|         |::..     |..|||:......
Mouse   284 CNVSDSKALLKCLREKSSLELMSLSQKAKSFTR---------VVDGS-----FFSEEPLELLSQK 334

  Fly   347 DFMKVPIITGMTKDEFVGPALSILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHY 411
            ....||.|.|:...| .|..|.:..:|.:|...||: .:|..:..:.:........:::|    |
Mouse   335 TLKIVPSIIGVNNQE-CGYILPVRDTPEILLGSNES-TALTLIHTLLHIPTQHLYIVTKE----Y 393

  Fly   412 F-----PDKLIDANRSLEALSNLYSDALTGFGIHRFVHLAARSTK-----VYYYRFSYQGARSHI 466
            |     |..:.|      .|.:|:.|..  |.:...|  .||..:     ||:|.|.:   |.|.
Mouse   394 FHGKHSPTDIRD------TLLDLFGDVF--FVVPGLV--TARYHRDSGGPVYFYEFQH---RPHC 445

  Fly   467 YYPEDAPYGVVHH-DDLMYLFVEPSISR---MFTEDDDEFRMVD-IMVRMFSAFAYKGDPNKPTD 526
            :......:....| |::.::|..|.:..   ||.|..:|.:::. .|::.::.||..|||| ..|
Mouse   446 FQNSRPAFVKADHTDEIRFVFGGPFLKGDVVMFEEATEEEKLLSRKMMKYWANFARSGDPN-GAD 509

  Fly   527 LALRDIRWRPFSFKKRYYLDIGKHITLEENLNAENYEIWKRLFPL 571
            |.    .| |...:...||::..:|:....|..:..|.|....||
Mouse   510 LP----PW-PVYDENEQYLELDVNISTGRRLKDQRVEFWTDTLPL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	157/557 (28%)
Ces5a	NP_001368779.1	COesterase	33..543	CDD:395084	157/557 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832472
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.990