DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and Bche

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	169/611 - (27%)
Similarity:	285/611 - (46%)	Gaps:	117/611 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGTILPSQSGRNFYAFRG 71
            ::||||.|....:::|                    |::|||..|::||..:|...| ...||.|
  Rat    10 WILLLCMLFGKSHTEE--------------------DVIITTKTGRVRGLSMPILGG-TVTAFLG 53

  Fly    72 IPYAKPPVDRLRFQPPEPVEQWFDTLDAT-------------FDGPKCPQLGLVSGDVSEDCLRV 123
            ||||:||:..|||:.|:|:.:|.|..:||             |.|.:..::...:.::|||||.:
  Rat    54 IPYAQPPLGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYL 118

  Fly   124 NIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQY---FMNR--RLVLVTFNYRLGS 183
            |::   :|.....|.  .|:|:::.|||     |:...:.|.|   |:.|  |:::|:.|||:|:
  Rat   119 NVW---IPVPKPKNA--TVMVWVYGGGF-----QTGTSSLPVYDGKFLTRVERVIVVSMNYRVGA 173

  Fly   184 LGFLA-TGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRG 247
            ||||| .|..||||||||.||...|:|::.:|:.|||:|.|:||.|..|||.:|:||::.|.|..
  Rat   174 LGFLAFPGNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYP 238

  Fly   248 LFHKAIVMSGAVTGQWSL--PDHQMDVATKQATLLHCHTENVTEMMDCLKGKHYLEFANTLPKMF 310
            ||.:||:.||:....|::  |:...:.....|..:.|..||..|::.||:.|.        |:
  Rat   239 LFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCSKENEKEIITCLRSKD--------PQ-- 293

  Fly   311 EFDRNNPLIL---------WKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEFVGPA 366
            |...|..|:|         :.|.::.|     ||.:.|....|........|:.|:.|||  |.|
  Rat   294 EILLNEKLVLPSDSIRSINFGPTVDGD-----FLTDMPHTLLQLGKVKTAQILVGVNKDE--GTA 351

  Fly   367 LSILQSP-------TLLSALNENFESLAPVFFMYNTSDARACNISQELRNHYFPDKLIDANRSLE 424
            ..:..:|       :|::  ...|:....::|      ....::.:|....|:.|.|.|  ::.|
  Rat   352 FLVYGAPGFSKDNDSLIT--RREFQEGLNMYF------PGVSSLGKEAILFYYVDWLGD--QTPE 406

  Fly   425 ALSNLYSDALTGFGI--------HRFVHLAARSTKVYYYRFSYQGARSHIYYPEDAPYGVVHHDD 481
            .....:.|.:..:.|        .:|..|   ....::|.|.::.  |.:.:||  ..||:|..:
  Rat   407 VYREAFDDIIGDYNIICPALEFTKKFAEL---EINAFFYYFEHRS--SKLPWPE--WMGVMHGYE 464

  Fly   482 LMYLFVEPSISRM-FTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRPFSFKKRYYL 545
            :.::|..|...|: :|..::.|..  .:::.::.||..|.||....   ....|..|:..::.||
  Rat   465 IEFVFGLPLERRVNYTRAEEIFSR--SIMKTWANFAKYGHPNGTQG---NSTVWPVFTSTEQKYL 524

  Fly   546 DIG-KHITLEENLNAENYEIWKRLFP 570
            .:. :...:...|.|...:.|:..||
  Rat   525 TLNTEKSKINSKLRAPQCQFWRLFFP 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	160/570 (28%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	161/593 (27%)
		Aes	<120..>272	CDD:223730	62/161 (39%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910