DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4382 and NLGN2

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	664	Identity:	189/664 - (28%)
Similarity:	281/664 - (42%)	Gaps:	152/664 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRLCGFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDL------VITTALGKIRGT--I 57
            ||.|   .|.|.|||..|.....     |....|.|....|..|      |:.||.|::||.  .
Human     1 MWLL---ALCLVGLAGAQRGGGG-----PGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRE 57

  Fly    58 LPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ-----LGLVSGDV- 116
            |.::.......|.|:|||.||:...||||||....|....:||...|.|||     |..:...|
Human    58 LNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVW 122

  Fly   117 ---------------SEDCLRVNIYTKELPSESQP---------------NVR----RPVIVFIH 147
                           |||||.:|:|   :|:|..|               ::|    :||::|:|
Human   123 FTDNLEAAATYVQNQSEDCLYLNLY---VPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLH 184

  Fly   148 PGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKL 212
             ||.| :.|....|.|........:::.|.|||||.||||:||.:.|.||.||.||:|.|||:..
Human   185 -GGSY-MEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSE 247

  Fly   213 HISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQA 277
            :|:.|||||..||:.|.||||..|.|.::|..|.|||.|||..||.....||:....:......|
Human   248 NIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLA 312

  Fly   278 TLLHCHTENVTEMMDCLKGKHYLEFA--NTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPI 340
            ..:.|..|:..|.::||:.|...|..  :..|..:.       |.:.||::.|     .:.::|.
Human   313 AKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYH-------IAFGPVVDGD-----VVPDDPE 365

  Fly   341 RSYQNDDFMKVPIITGMTKDEFVGPALSILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQ 405
            ...|..:|:...::.|:.:    |..|..::.    ||.:|:..|.:...|          .:|.
Human   366 ILMQQGEFLNYDMLIGVNQ----GEGLKFVED----SAESEDGVSASAFDF----------TVSN 412

  Fly   406 ELRNHY-FPDKLIDANRSLEALSNLYSD-------------ALTGFGIHRFVHLAARSTK----- 451
            .:.|.| :|:.. |..|  |.:..:|:|             .|..|..|::|..|..:.|
Human   413 FVDNLYGYPEGK-DVLR--ETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADY 474

  Fly   452 ---VYYYRFSY----QGARSHIYYPE--DAPYGVVHHDDLMYLFVEPSISRM------FTEDDDE 501
               ||:|.|.:    :|.      ||  ||.:|    |:|.|:|..|.:...      |:::|
Human   475 QSPVYFYTFYHHCQAEGR------PEWADAAHG----DELPYVFGVPMVGATDLFPCNFSKND-- 527

  Fly   502 FRMVDIMVRMFSAFAYKGDPNKPTDL----------ALRDIRWRPFSFKKRYYLDIGKHITLEEN 556
            ..:..:::..::.||..||||:|...          ...::.|..|:.|::.||.||....:.:|
Human   528 VMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDN 592

  Fly   557 LNAENYEIWKRLFP 570
            ..|.....|..|.|
Human   593 YRANKVAFWLELVP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	174/617 (28%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	172/609 (28%)
		Aes	<170..>268	CDD:223730	45/99 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142793
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740