DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4382 and cel.2

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001020344.2	Gene:	cel.2 / 565117	ZFINID:	ZDB-GENE-061110-10	Length:	551	Species:	Danio rerio

Alignment Length:	575	Identity:	163/575 - (28%)
Similarity:	252/575 - (43%)	Gaps:	93/575 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LVITTALGKIRGTILPSQSG------------RNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDT 96
            |.:.||.|...|.:| ::.|            |....|:|||:|.||.   |.|.|.|...|...
Zfish    13 LFLGTAQGASLGAVL-TEGGMVQGKSHSVGLLRYMDVFKGIPFAAPPG---RLQKPVPHPGWEGV 73

  Fly    97 LDATFDGPKCPQLGLVSGDV--SEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSK 159
            |.||....:|.||.|:..|.  |||||.:||:   :|.....:...||:|||:.|||....||..
Zfish    74 LKATEYSKRCIQLNLLQTDTMGSEDCLYLNIW---VPQGKTVSYNLPVMVFIYGGGFLLGGGQGA 135

  Fly   160 NFA------GPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFG 218
            ||.      |.:......:::||||||:||:|||:||..:||||.||.||...:.||..:|..||
Zfish   136 NFLDNYLYDGEEIADRGNVIVVTFNYRVGSMGFLSTGDADAPGNYGLWDQHAAISWVHRNIKAFG 200

  Fly   219 GDPSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCH 283
            |:|.:||:.|..||:.:|...::||.::||..:||..||.....|::..:....|.:.|..:.|.
Zfish   201 GNPDNITIFGESAGSTSVNFQIISPKNKGLIRRAISQSGVALCPWAINRNPRKFAEEIAKKVGCP 265

  Fly   284 TENVTEMMDCLK----------GKHYLEFANTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEE 338
            |:  :.|:.||:          ||..|..:.|.|.:..       :...|||:.|     |:.:|
Zfish   266 TD--SGMVACLRRTDPKAVTLAGKVRLATSATEPIVHN-------LYLSPVIDGD-----FIPDE 316

  Fly   339 PIRSYQNDDFMKVPIITGMTKDEFVGPALSILQSPTLLSAL----NENFESLAPVFFMYNTSDAR 399
            |...:.|  ...:..|.|:  ::..|...:.|..|::.:||    .|..::||.........||.
Zfish   317 PDTLFGN--AADIDYIAGV--NDMDGHIFATLDIPSINNALATTTEEEVQALATALSKDRGQDAG 377

  Fly   400 ACNISQELRNHYFPDKLIDANRSLEALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSYQGARS 464
            .....:...|........|..:::..:...|            :.|....|.:|.:..:.:.||:
Zfish   378 IATFQEYTVNWGSKPNKEDIKKTVVEMETDY------------IFLVPTQTALYLHSDNAKSART 430

  Fly   465 HIYYPEDAP--------YGVVHHDDLMYLFVEPSISRMFTEDDDEF-RMVDI---MVRMFSAFAY 517
            :.|...::.        .|..|.|:|.|:|.:|     ||.....| |..|:   |:..::.||.
Zfish   431 YSYLFSESSRIPIFPLWMGADHADELQYVFGKP-----FTTPLGYFPRHRDVSKYMIAYWTNFAQ 490

  Fly   518 KGDPNKPTDLALRDIRWRPFSFKKRYYLDIGKHI---TLEENLNAENYEIWKRLF 569
            .|:||  |..:...:.|..||.....||||...|   ::::.|.......|..:|
Zfish   491 TGNPN--TGESKVPVTWPEFSNPGHQYLDINNKINTNSVKKMLRTRLVYYWTTVF 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	161/569 (28%)
cel.2	NP_001020344.2	COesterase	26..539	CDD:306613	156/556 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575585
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740