DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and Ces2h

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001258974.1	Gene:	Ces2h / 436059	MGIID:	3648740	Length:	558	Species:	Mus musculus

Alignment Length:	602	Identity:	163/602 - (27%)
Similarity:	253/602 - (42%)	Gaps:	110/602 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CGFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGTILPSQS-GRNFYA 68
            ||.:|||  ...||           |...||.          ||..|:|.|:::..:. ....::
Mouse    15 CGLLLLL--RVQGQ-----------DSTSPIR----------TTHTGQILGSLIHMKDLDVGVHS 56

  Fly    69 FRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ--------------LGLVSGDVSED 119
            |.|||:|||||..|||.||||.|.|....|.|.....|.|              |.|....:|||
Mouse    57 FLGIPFAKPPVGPLRFAPPEPPEPWGGVRDGTSHPAMCLQDITAMNMQAFKLLKLTLPPFPMSED 121

  Fly   120 CLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSL 184
            ||.:|||.   |..:......||:|:||.|..  :.|.:..:.|........:|:||..||||.|
Mouse   122 CLYLNIYA---PDHAHEGSNLPVMVWIHGGSL--VIGMASMYDGSMLAAMENVVVVTIQYRLGVL 181

  Fly   185 GFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGLF 249
            ||.:||...|.||.|..|||..|||::.:|:.|||:|..:|:.|..||..:|:..:|||||:|||
Mouse   182 GFFSTGDERARGNWGYLDQVAALRWLQQNIAYFGGNPDRVTIFGTSAGGTSVSSLVVSPMSQGLF 246

  Fly   250 HKAIVMSGAVTGQWSLPDHQMDVATKQ-ATLLHCHTENVTEMMDCLKGKHYLEFANTLPKMFEFD 313
            ..||:.||..... ||.....||..:. |.|..|...:...:::||:||...|.. .:.|.|:
Mouse   247 RGAIMESGVALIS-SLISVSSDVVYQTVANLSGCEQVDSEALVNCLRGKSEEEIM-AINKAFK-- 307

  Fly   314 RNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEF---VGPALSILQSPTL 375
                       |.|......||...|.....:.||..||.|.|:..||:   :..::|::.|...
Mouse   308 -----------IIPGIVDGIFLPRHPQELMASADFHPVPSIIGVNNDEYGWIIPSSMSMIDSKKG 361

  Fly   376 LSALNENFESLAPVFFMYNTSDARACNISQELRNHYFPDKLIDANRSLEALSNLYSDALTGFGIH 440
            :..     :.:..:.....|.......:|..|...|..|     |...:.|...:.:.:..|
Mouse   362 MDR-----QMVQAILQRRATQMMWPPEVSDLLMEEYMGD-----NEDPQFLQVQFKEMMKDF--- 413

  Fly   441 RFVHLAARSTK-------VYYYRFSYQGARSHIYYPEDAPYGVV--HHDDLMYLF--------VE 488
            .||..|.:..:       |::|.|.::.:    ::.:..|..|.  |.|:::::|        |:
Mouse   414 TFVIPALQVAQFQRSHAPVFFYEFQHRPS----FFKDSKPSHVKADHGDEILFIFRSFWGGTQVD 474

  Fly   489 PSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRPFSFKKRYYLDIGKHITL 553
                  |||:::  .:...|::.::.||.:.:||.      ..:.:.|...:...||.:.....:
Mouse   475 ------FTEEEE--LLSRRMMKYWANFARQRNPNS------EGLPYWPMFDQDEQYLQLDTQPAV 525

  Fly   554 EENLNAENYEIWKRLFP 570
            ...|.....:.|.:..|
Mouse   526 GRALKTRRLQFWTKTLP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	151/559 (27%)
Ces2h	NP_001258974.1	COesterase	30..537	CDD:278561	153/567 (27%)
Ces2h	NP_001258974.1	Aes	<127..>230	CDD:223730	41/107 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832882
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890