DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and alpha-Est3

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001163540.1	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	171/567 - (30%)
Similarity:	252/567 - (44%)	Gaps:	72/567 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LSDLVITTALGKIRGTILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPK 105
            :..|.:.|..|.:.|.......|..:.:|..||||:|||..|||..|.|||.|...||.|..|.|
  Fly     1 MESLQVNTTSGPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQK 65

  Fly   106 CPQLGLVSGDVS--EDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFM 168
            ..|....|..:.  ||||.:|:|.|||.| .:|   .|:|||...||| .....:|....|.|||
  Fly    66 PLQFNHYSKQLEGVEDCLYLNVYAKELDS-PRP---LPLIVFFFGGGF-EKGDPTKELHSPDYFM 125

  Fly   169 NRRLVLVTFNYRLGSLGFL-----ATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLG 228
            .|.:|:||.:||:|.||||     |.|   .|||.|||||:..:.|:|.:..||.|||.::|..|
  Fly   126 MRDVVVVTVSYRVGPLGFLSLNDPAVG---VPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFG 187

  Fly   229 YGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQW------SLPDHQMDVATKQATLLHCHTENV 287
            ..|||.:|...|::|.:.|||||||:.||.|...|      :|| |::.|.....:     .|:|
  Fly   188 ESAGAASVHYLMLNPKAEGLFHKAILQSGNVLCSWALCTIKNLP-HRLAVNLGMES-----AEHV 246

  Fly   288 TEMMDCLKGKHYLEFANTLPK------------------MFEFDRNNPLILWKPVIEPDFGQERF 334
            |:.|       .|:|...||.                  :|:|.         |::||...:...
  Fly   247 TDAM-------VLDFLQKLPGEKLVRPYLLSAEEHLDDCVFQFG---------PMVEPYKTEHCA 295

  Fly   335 LVEEPIRSYQNDDFMKVPIITGMTKDEFVGPALSILQSPTLLSALNENFESLAPVFFMYNTSDAR 399
            |...|..........::|::...|..|.:.....:..:|.||::|.:..|.:.|:....|...|.
  Fly   296 LPNHPQELLDKAWGNRIPVLMSGTSFEGLLMYARVQMAPYLLTSLKKEPEHMLPLDVKRNLPQAL 360

  Fly   400 ACNISQELRNHYF--PDKLIDANRSLEALSNLYSDALTGFGIHRFV--HLAARSTKVYYYRFSYQ 460
            |.::.|.|:..:|  .|....:..||:|.....|..:....|.:.:  .:.:.|...|.|||.:.
  Fly   361 ARHLGQRLQETHFGGNDPSAMSPESLKAYCEYASYKVFWHPILKTLRSRVKSSSASTYLYRFDFD 425

  Fly   461 GA---RSHIYYPEDAPYGVVHHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPN 522
            ..   ...:.|..|...||.|.||..||:. ...|....:...||..::.|:.|.::||...:||
  Fly   426 SPTFNHQRLKYCGDKLRGVAHVDDHSYLWY-GDFSWKLDKHTPEFLTIERMIDMLTSFARTSNPN 489

  Fly   523 KP--TDLALRDIRWRPFSFKKRY-YLDIGKHITLEENLNAENYEIWK 566
            ..  .|...|...|:|.:.|... .|:|.::|.:.|....:...:|:
  Fly   490 CKLIQDQLPRAKEWKPLNSKSALECLNISENIKMMELPELQKLRVWE 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	170/564 (30%)
alpha-Est3	NP_001163540.1	Abhydrolase	3..529	CDD:304388	170/556 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467403
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.790