DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and alpha-Est8

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	176/555 - (31%)
Similarity:	263/555 - (47%)	Gaps:	43/555 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SDLVIT-TALGKIRGTILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPK 105
            :|.||. |..||::|....|..|.|:|:|.|||:|||||..|||:.|...|.|.|....|....|
  Fly    30 NDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAK 94

  Fly   106 CPQLGLVSGDV--SEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFM 168
            ..|:.:|...|  |||||.:|:||:||    .|:...||:|:|:.||| .:...|::...|.|.|
  Fly    95 PCQVNIVLKQVQGSEDCLYLNVYTREL----HPHRPLPVLVWIYGGGF-QMGEASRDLYSPDYIM 154

  Fly   169 NRRLVLVTFNYRLGSLGFLATGTRE--APGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGA 231
            ...:|||..:||||:||||:....|  .|||.||||||..|||||.:...|||||.:||:.|..|
  Fly   155 MEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESA 219

  Fly   232 GAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWS-LPDH-QMDVATKQATLLHCHTENVTE----- 289
            |..:....|::..::|||||.|:|||:....|: .|.| .......|||   .:|.:..:
  Fly   220 GGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQAT---GYTGDANDRDIFA 281

  Fly   290 -MMDCLKGKHYLEFANTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPI 353
             :..| |....|:.|..:..|.|..:...:..:.|.|||.......:.:.|:...::.....:|:
  Fly   282 HLKKC-KASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPM 345

  Fly   354 ITGMTKDEFVGPALSILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHYFPDKLID 418
            :.|....|.:.....:.:.|.||..|.: .|:|||.....:....:|  ..:::|..||.|:...
  Fly   346 VIGGNSFEGLLMFPEVNKWPELLCQLGD-CENLAPQDAHVDEQQRKA--FGKKVRELYFGDRTPG 407

  Fly   419 ANRSLEALSNLYSDALTGFGIHRFVHLAARSTKV---YYYRFSYQGARSHIYYPEDA---PYGVV 477
            ....|| .|:|:|......||||.:...|....:   :.|||.:.....:|......   ..|..
  Fly   408 RKTILE-YSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGTC 471

  Fly   478 HHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIR------WRP 536
            |.|||.|||...:..:: .....||:.:..:|.|...||..||||.|  :..:|.:      |.|
  Fly   472 HADDLSYLFYNAAAKKL-KRRTAEFKTIKRLVSMVVHFAISGDPNIP--MVCQDEKEQPRGAWLP 533

  Fly   537 FSFKKRYY--LDIGKHITLEENLNAENYEIWKRLF 569
            .|...:.:  |:|...:.:.:...||...:|..::
  Fly   534 ISKDDKVFQCLNISHDVHVIDLPEAEKLRLWDCIY 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	175/549 (32%)
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	175/549 (32%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	51/109 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467391
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.790