DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and alpha-Est9

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	174/567 - (30%)
Similarity:	265/567 - (46%)	Gaps:	60/567 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VITTALGKIRGTILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQL 109
            |::|..|.|:|....|..|:::::|..||:|||||..||::.|:|.|.|.:....|..|||..|.
  Fly    33 VVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPLQK 97

  Fly   110 GLV--SGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRL 172
            ..|  ..|.|||||.:|:|||.|    .|....||:|:|:.||| .....|:....|.|.:...:
  Fly    98 HFVFEMTDGSEDCLYLNVYTKNL----YPTKPMPVMVWIYGGGF-QFGEASRECYSPDYLLREDV 157

  Fly   173 VLVTFNYRLGSL------------------GFLATGTRE--APGNMGLKDQVQLLRWVKLHISRF 217
            |:::.|||||.|                  |||.....|  .|||.||||||..|||||.:.|||
  Fly   158 VVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCSRF 222

  Fly   218 GGDPSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQ---MDVATKQATL 279
            |||.::||:.|..||:.:|...|::..:.|||||||.|||.....|::...:   ..:|.:....
  Fly   223 GGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRNWPYRLAVQAGYA 287

  Fly   280 LHCHTENVTEMMDCLKGKHYLEFANTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQ 344
            ...:|.:|.|.:...||...:: ||....:.|..:......:.|||||.......:.::||...:
  Fly   288 GENNTRDVWEFLKNAKGSEIIK-ANGELCIDEEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMR 351

  Fly   345 NDDFMKVPIITGMTKDEFVGPALSILQSPTLLSALNE--NFESLAPVFFMYNTSDARACNISQEL 407
            ......:|:|.|...:|.:   |...::.|....|||  :...:.|:....:...|.......:|
  Fly   352 TAWSNNIPLIIGGVSNEGL---LLYSETKTNPKCLNELDDCRFVVPIELNMDRESALCREYGDQL 413

  Fly   408 RNHYFPDKLIDANRSLEALS---NLYSDALTGFGIHRFVHLA----ARSTKVYYYRFSYQGAR-S 464
            |..|:.||    ..||:.|.   .:.|.....|.|:|.| |:    |||...|.|||.:.... :
  Fly   414 RQCYYGDK----TPSLDTLHEYLQMVSHEYFWFPIYRTV-LSRLQYARSAPTYLYRFDFDSKHFN 473

  Fly   465 H--IYYPEDAPYGVVHHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDL 527
            |  |........|..|.|||.|||.. |::|.......|::.::.:|.:::.||..|:||  .|.
  Fly   474 HLRILSCGKKVRGTCHGDDLSYLFYN-SLARKLKNHTREYKCIERLVGLWTHFAACGNPN--FDP 535

  Fly   528 ALRDIRWRPF---SFKKRYY--LDIGKHITLEENLNAENYEIWKRLF 569
            ...|: |:|.   :.:|...  |:|...:.:.:..:.:...:|:..|
  Fly   536 EQEDL-WQPVDPAAVEKHQLKCLNISDELKVIDVPDLKKLMVWESFF 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	172/561 (31%)
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	170/539 (32%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	49/126 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467418
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.790