Protein Alignment CG4382 and AADACL2

DIOPT Version :10

• Sequence 1: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_997248.2
• Gene: AADACL2 / 344752
• HGNCID: 24427
• Length: 401
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 83/373 - (22%)
• Similarity: 138/373 - (36%)
• Gaps: 110/373 - (29%)

  Fly    81 RLRFQPPEPVEQWFDTLDATF-DGPKCPQLGLVSGDVSEDCLRVNIYTKELPSESQPNVRRPVIV 144
            ||.:..|.. :::....|.|| |.|                  |.:|..:..||:    ||..::
Human    67 RLDYTQPLS-DEYITVTDTTFVDIP------------------VRLYLPKRKSET----RRRAVI 108

  Fly   145 FIHPGGFYSLSGQSKNFAGPQYFMNR------RLVLVTFNYRLGSLGFLATGTREAPGN---MGL 200
            :.|.|||...|.:.:.|.    |:||      ..|:|..:|||            ||.:   ...
Human   109 YFHGGGFCFGSSKQRAFD----FLNRWTANTLDAVVVGVDYRL------------APQHHFPAQF 157

  Fly   201 KDQVQLLRWVKLH--ISRFGGDPSSITLLGYGAG---AMAVTLHMVSPMSRGLFHK----AIVMS 256
            :|.:..:::..|.  ::::|.||:.|.:.|..:|   |.|||..:.:...  :.||    .::..
Human   158 EDGLAAVKFFLLEKILTKYGVDPTRICIAGDSSGGNLATAVTQQVQNDAE--IKHKIKMQVLLYP 220

  Fly   257 GAVTGQWSLPDHQ---------MDVATKQATLLHCHTENVTEMMD-----CLKGKHYLEFANTLP 307
            |.......||.|:         .|||.|..:|.....|.:...|.     .|:.:|..:|.|
Human   221 GLQITDSYLPSHRENEHGIVLTRDVAIKLVSLYFTKDEALPWAMRRNQHMPLESRHLFKFVN--- 282

  Fly   308 KMFEFDRNNPLILWKPVIEPDFGQERFLVEEPI---RSYQNDDFMKVPIITGMTKDEFVGPAL-- 367
                         |. ::.|:..::.::..|||   .||.         :.|:| |....|.|
Human   283 -------------WS-ILLPEKYRKDYVYTEPILGGLSYS---------LPGLT-DSRALPLLAN 323

  Fly   368 -SILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHYFPD 414
             |.||:..|...|....:.|.....||.|   |..|:..::.:.:..|
Human   324 DSQLQNLPLTYILTCQHDLLRDDGLMYVT---RLRNVGVQVVHEHIED 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	42..565	CDD:395084	83/373 (22%)
AADACL2	NP_997248.2	Abhydrolase_3	107..372	CDD:400284	69/310 (22%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)