DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and CG6414

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	192/553 - (34%)
Similarity:	289/553 - (52%)	Gaps:	51/553 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GKIRGTILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQLGLVSGD 115
            |.:.|..|.:.:||:..||.|:|||:||:|.|||:||.|...|.....|..|.|.|.|......|
  Fly    38 GWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFRRD 102

  Fly   116 V----SEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVT 176
            :    |||||.:|:||.|.|   :.|...||:|:.|.||:...||.| :|.||.:.::..:|||:
  Fly   103 MILEGSEDCLYLNVYTPERP---RTNGSLPVMVWFHGGGWQCGSGIS-SFYGPDFLLDHDIVLVS 163

  Fly   177 FNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMV 241
            .|:|||.||||:|.|.:.|||.|||||:::|.||:.:|:.|||||:|:|:.|..||..:||.||:
  Fly   164 ANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHML 228

  Fly   242 SPMSRGLFHKAIVMSGAVTGQWSLPDHQ---MDVATKQATLLHC-HTENVTEMMDCLKGKHYLEF 302
            |..||||.|:.|..||.....|:.|.|:   ...|||.|.::.| :.....|.::||:.|...:.
  Fly   229 SEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDI 293

  Fly   303 ANTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEFVGPAL 367
            ..:|..||.:| .:|:|.:.||:||:. ...||...| |.......:::|::.|.|.:|.:....
  Fly   294 VASLYDMFVWD-FDPMIPFPPVVEPEH-DGAFLTVAP-RQAAKPHGLQLPLMVGATAEEGLLKTA 355

  Fly   368 SILQSPTLLSALNENFESLAPVFFMY-NTSDARACNISQELRNHYFP-----DKLIDANRSLEAL 426
            ::|..|.||:.....||.:.||...| :..|:....|:|.:.:.||.     ||   ||.  :.|
  Fly   356 ALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGHDYDK---ANH--QNL 415

  Fly   427 SNLYSDALTGFGIHRFVHLAARSTKV---YYYRFSYQGARSHIYYPE------DAPYGVVHHDDL 482
            ::|.||.....||..::.|......|   |.|.|.::||.|   :.|      :..||..|.::|
  Fly   416 TDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAAS---FTEIFKGGRNEFYGACHAEEL 477

  Fly   483 MYLFV---EPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRPFSFKKRYY 544
            .|||.   |..:|.:.|:.|.|.|  ::|:.::.:||..|:|| ||:::.....|.|.|.....:
  Fly   478 QYLFPIGRELFVSAVPTQKDLELR--ELMLHLWVSFAKTGNPN-PTNVSFHLPNWSPASSYPVEF 539

  Fly   545 LDIGKHI-------TLEENLNAENYEIWKRLFP 570
            ..:|..:       .||..|.....:.|:.|.|
  Fly   540 ARLGTKMEDSASIFRLENELMQHRVDFWRDLQP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	189/546 (35%)
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	189/546 (35%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	66/141 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102505at50557
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.970