DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and Ces2i

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_008758816.2	Gene:	Ces2i / 292152	RGDID:	1565045	Length:	558	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	170/620 - (27%)
Similarity:	244/620 - (39%)	Gaps:	146/620 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CGFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGT---ILPSQSGRNF 66
            ||.:|||..: .||           |...||.:          |..|::||:   :..::||  .
  Rat    15 CGLLLLLQHV-HGQ-----------DSASPIRN----------TQTGQVRGSFVHVKDTKSG--V 55

  Fly    67 YAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQLGLVSGD-------------VSE 118
            :.|.|||:|||||..|.|.|||..|.|....|.|.....|.|..::..|             :||
  Rat    56 HTFLGIPFAKPPVGPLHFAPPEDPEPWSGVRDGTSQPDMCLQTDIMKEDFIKEMKLTMHPTPMSE 120

  Fly   119 DCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGS 183
            |||.:||||   |:.::.....||:|:||.||.. |...|.|.|. .......:|:|...||||.
  Rat   121 DCLYLNIYT---PAHAREGSNLPVMVWIHGGGLV-LGSASMNVAS-TLAATEEIVIVAIQYRLGI 180

  Fly   184 LGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGL 248
            |||.:||...|.||.|..|||..|.||:.:|:.|||:...:|:.|..||..:|:.|:|||||:||
  Rat   181 LGFFSTGDEHARGNWGYLDQVAALCWVQQNIAYFGGNHGKVTIFGVSAGGTSVSSHVVSPMSKGL 245

  Fly   249 FHKAIVMSGAVTGQWSLPDHQMD----VATKQATLLHCHTENVTEMMDCLKGKHYLEF--ANTLP 307
            ||.||:.||...    |||...|    |....|.|..|...:...::.||:.|...|.  .|.:.
  Rat   246 FHGAIMQSGVAL----LPDLISDTSEVVYKTVANLSGCEASDSEALIRCLRAKSKQEILAINQVF 306

  Fly   308 KMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDE-------FVG- 364
            ||.                |.....:||.:.|.....:.||..||.|.|:..||       |:|
  Rat   307 KMI----------------PGVVDGKFLPKHPQELLASGDFHPVPSIIGVNTDECGLGVPMFMGL 355

  Fly   365 ------------------PALSILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHY 411
                              .|..::..|..:..:.|.        :|.:|.|       .|.....
  Rat   356 DHIIKKITRDTLPTVLKSTAAQMMLPPECIDLIMEE--------YMGDTED-------PETLQEQ 405

  Fly   412 FPDKLIDANRSLEALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSY------QGARSHIYYPE 470
            |.:.|.|....:.||              ...|.......||:|.|.:      |...||:
  Rat   406 FKEMLGDFMFVIPAL--------------EVAHFQRSQAPVYFYEFQHLPSFIKQVRPSHV---- 452

  Fly   471 DAPYGVVHHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWR 535
                ...|.||::::|........|...::|..:...:::.::.||..|:||.      .|:.:.
  Rat   453 ----KADHGDDILFVFSSYFWGMNFDITEEEELLKRRVMKYWANFARNGNPNS------EDLPYW 507

  Fly   536 PFSFKKRYYLDIGKHITLEENLNAENYEIWKRLFP 570
            |.......||.:.....:...|.|...:.|.:..|
  Rat   508 PVLDHNEQYLQLNTQPAVGRALKARRLQFWTKTLP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	158/577 (27%)
Ces2i	XP_008758816.2	COesterase	30..537	CDD:395084	160/586 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336245
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.990