DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4382 and Ces2g

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001099645.1	Gene:	Ces2g / 291952	RGDID:	1308358	Length:	560	Species:	Rattus norvegicus

Alignment Length:	594	Identity:	167/594 - (28%)
Similarity:	258/594 - (43%)	Gaps:	90/594 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LCGFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGTILPSQSGRN-FY 67
            |.|.:|||..: .||:|.|                   |..:..|..|:::|.:..|:..:: .:
  Rat    14 LFGLLLLLIHV-QGQHSPE-------------------SSPIRNTHTGQVQGKLTHSKDFKSGVH 58

  Fly    68 AFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ-------------LGLVSGDVSED 119
            .|.|||:||.||..|||.|||..|.|....|.|.....|||             |.|....:|||
  Rat    59 TFLGIPFAKAPVGPLRFAPPEAPEPWSGVRDGTSQSNICPQNVRMNMEGLKEMKLTLPPVSMSED 123

  Fly   120 CLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSL 184
            ||.:|||.   |:.:......||:|:|| ||..:: |.:..:.|........:|:||..||||.|
  Rat   124 CLYLNIYA---PAHAHEGSHLPVMVWIH-GGALTV-GMASMYDGSMLAATEDVVVVTIQYRLGVL 183

  Fly   185 GFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGLF 249
            ||.:||...|.||.|..|||..||||:.:|:.|||:|..:|:.|..||.::|:.|:|||||:|||
  Rat   184 GFFSTGDHHARGNWGYLDQVAALRWVQQNIAHFGGNPDCVTIFGESAGGLSVSSHVVSPMSKGLF 248

  Fly   250 HKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTENVTEMMDCLKGKHYLEFANTLPKMFEFDR 314
            |:||:.||......::.:....|......|..|...:...::.||:||.. |....:.|.|:
  Rat   249 HRAIMESGVALMPGTIFNFSEMVYQMVVKLSGCEAMDPESLVHCLRGKSE-EQITVISKEFQ--- 309

  Fly   315 NNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEF--VGPALSILQSPTLLS 377
                      :.|......||...|.....:.||..||.|.|...||:  :.|.: |..:.|:..
  Rat   310 ----------MIPAVVDGEFLPNHPQELLASADFHPVPSIIGFNNDEYGWIVPKV-IGSAQTIKG 363

  Fly   378 ALNENFESLAPVFFMYNTSDARAC--NISQELRNHYFPDKLIDANRSLEA-LSNLYSD---ALTG 436
            ...||.::     |:.:|:.....  ..|..|...|..|  |:..::|:| .:.:..|   .:..
  Rat   364 ITRENLQA-----FLKDTAPQMMLPPECSDLLMEEYMGD--IEDPQTLQAQFTEMMEDFMFVIPS 421

  Fly   437 FGIHRFVHLAARSTKVYYYRFSYQGARSHIYYPEDAPYGVV--HHDDLMYLFVEPSISRMFTEDD 499
            ..:.||....|   .||:|.|.:|.:    :..:..|..|.  |.|::.::|............:
  Rat   422 LQVARFQRSHA---PVYFYEFQHQSS----FLKDIRPPHVKADHGDEVPFVFGSFFWGMKLNLTE 479

  Fly   500 DEFRMVDIMVRMFSAFAYKGDPNK---PTDLALRDIRWRPFSFKKRYYLDIGKHITLEENLNAEN 561
            .|..:...|::.::.||..|:||.   |        .|..|.:.:: ||.:.....:.....|..
  Rat   480 GEKLLNRRMMKYWANFARYGNPNSNSLP--------YWPVFDYDEQ-YLQLNTQPAVGRIQKARK 535

  Fly   562 YEIWKRLFP 570
            .:.|.:..|
  Rat   536 LQFWTKTLP 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	156/550 (28%)
Ces2g	NP_001099645.1	COesterase	31..539	CDD:278561	157/569 (28%)
Ces2g	NP_001099645.1	Aes	<129..>232	CDD:223730	43/107 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336296
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm45901
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.890