Protein Alignment CG4382 and CES4A

DIOPT Version :10

• Sequence 1: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 665
• Identity: 169/665 - (25%)
• Similarity: 270/665 - (40%)
• Gaps: 170/665 - (25%)

  Fly     2 WRLCGFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIR----------GT 56
            |.|| :.|.||                               |:..||||.:.          ||
Human    26 WILC-WSLTLC-------------------------------LMAQTALGALHTKRPQVVTKYGT 58

  Fly    57 ILPSQS--GRN-FYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGP-------------- 104
            :...|.  |:. ...|.|:|:::||:..|||.||||.|.|....|||...|
Human    59 LQGKQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWSLALSPGWSAVA 123

  Fly   105 --------------------------KCPQLG---LVSGDV-----------SEDCLRVNIYTKE 129
                                      :|.|..   |.|..|           |||||.:|:|.
Human   124 RSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFSEDCLYLNVYA-- 186

  Fly   130 LPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGFL----ATG 190
             |:.:..:.:.||:|:. |||.: :.|.:.::.|.......::|||...:|||..|||    .|.
Human   187 -PARAPGDPQLPVMVWF-PGGAF-IVGAASSYEGSDLAAREKVVLVFLQHRLGIFGFLRWRGRTD 248

  Fly   191 TREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVM 255
            ...|.||.||.||:..||||:.:|:.|||||.::||.|..||||:::..|:||::.||||:||..
Human   249 DSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQ 313

  Fly   256 SGAVTGQWSLPDHQMDVATKQATLLHCHTENVTEMMDCLK---GKHYLEFANTLPKM-FEFDRNN 316
            ||....:..:..:.:.||.|.|.|..|:..:...:::||:   |...:..:|.:..: ..|.|:.
Human   314 SGTALFRLFITSNPLKVAKKVAHLAGCNHNSTQILVNCLRALSGTKVMRVSNKMRFLQLNFQRDP 378

  Fly   317 PLILW--KPVIE----PDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEFVGPALSILQSPTL 375
            ..|:|  .||::    ||         :|:..........||.:.|:...||......|::.|..
Human   379 EEIIWSMSPVVDGVVIPD---------DPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMKFPLN 434

  Fly   376 LSALNENFESLAPVFFMYNTSDARACNISQE---------LRNHYFPDKLIDANRSLEALSN--- 428
            ..|:.:  |::..:.:...|    ..||::|         |.|....|..:..||.::.:.:
Human   435 RQAMRK--ETITKMLWSTRT----LLNITKEQVPLVVEEYLDNVNEHDWKMLRNRMMDIVQDATF 493

  Fly   429 LYSDALTGFGIHRFVHLAARSTKVYYYRFSYQGARSHIYYPEDAPYGVVHHDDLMYLFVEPSISR 493
            :|:...|.. .||...|     .||.|.|.:. ||..|..|...  |..|.|::.:||..|..:.
Human   494 VYATLQTAH-YHRDAGL-----PVYLYEFEHH-ARGIIVKPRTD--GADHGDEMYFLFGGPFATG 549

  Fly   494 MFTEDDDEFRMVDIMVRMFSAFAYKGDPNK---PTDLALRDIRWRPFSFKKRY-YLDIGKHITLE 554
            :....:....:.  |::.::.||..|:||.   |.        |..::..::| .||....:.::
Human   550 LSMGKEKALSLQ--MMKYWANFARTGNPNDGNLPC--------WPRYNKDEKYLQLDFTTRVGMK 604

  Fly   555 ENLNAENYEIWKRLF 569
              |..:....|..|:
Human   605 --LKEKKMAFWMSLY 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	42..565	CDD:395084	161/619 (26%)
CES4A	XP_011521323.1	COesterase	50..613	CDD:395084	156/603 (26%)