DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and Ces2a

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	172/620 - (27%)
Similarity:	252/620 - (40%)	Gaps:	146/620 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CGFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGT---ILPSQSGRNF 66
            ||.:|||..: .||           |...||.:          |..|::||:   :..::||  .
  Rat    15 CGLLLLLQHV-HGQ-----------DSASPIRN----------THTGQVRGSFVHVKDTKSG--I 55

  Fly    67 YAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQLGLVSGD-------------VSE 118
            :.|.|||:|||||..|||.|||..|.|....|||.....|.|..:::.|             :||
  Rat    56 HTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPMSE 120

  Fly   119 DCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGS 183
            |||.:||||   |:.::.....||:|:||.||.. |...|.|.|. .......:|:|:..||||.
  Rat   121 DCLYLNIYT---PAHAREGSNLPVMVWIHGGGLV-LGSASMNDAS-TLAATEEIVIVSIQYRLGV 180

  Fly   184 LGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGL 248
            |||.:||.:.|.||.|..|||..||||:.:|:.|||:...:|:.|..||..:|:.|:|||||:||
  Rat   181 LGFFSTGDQNARGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGL 245

  Fly   249 FHKAIVMSGAVTGQWSLPD---HQMDVATKQ-ATLLHCHTENVTEMMDCLKGKHYLEF--ANTLP 307
            ||.||:.||...    |||   .:.:|..|. |.|..|...:...::.||:.|...|.  .|.:.
  Rat   246 FHGAIMQSGVAL----LPDLISDKSEVVYKTVANLSGCEAPDSEALIRCLRAKSKQEILAINQVF 306

  Fly   308 KMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDE-------FVG- 364
            ||.                |.....:||.:.|.....:.||..||.|.|:..||       |:|
  Rat   307 KMI----------------PGVVDGKFLPKHPQELLASGDFHPVPSIIGINTDECGWGIPVFLGL 355

  Fly   365 ------------------PALSILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHY 411
                              .|..::..|..:..:.|.        :|.:|.:....   ||...|.
  Rat   356 DHIIKKITRETLPTVLKSTAAQMMLPPECIDLIMEE--------YMGDTENPETL---QEQFRHM 409

  Fly   412 FPDKLIDANRSLEALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSY------QGARSHIYYPE 470
            ..|.:.    .:.||              :..|.......||:|.|.:      |...||:
  Rat   410 LGDFMF----VIPAL--------------QVAHFQRSQAPVYFYEFQHLPSFIKQVRPSHV---- 452

  Fly   471 DAPYGVVHHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWR 535
                ...|.||::::|........|...::|..:...:::.::.||..|:||.      .|:...
  Rat   453 ----KADHGDDILFVFGSYLWGMTFDLTEEEELLKRRVMKYWANFARTGNPNG------EDLPHW 507

  Fly   536 PFSFKKRYYLDIGKHITLEENLNAENYEIWKRLFP 570
            |.......||.:.....:...|.|...:.|.:..|
  Rat   508 PVLDHDEQYLQLNTQPAVGRALKARRLQFWTKTLP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	160/577 (28%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	162/586 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336228
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.990