Protein Alignment CG4382 and CES3

DIOPT Version :10

• Sequence 1: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 163/593 - (27%)
• Similarity: 258/593 - (43%)
• Gaps: 113/593 - (19%)

  Fly    40 ELSDLVITTALGKIRGTILPSQSG-----RNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDA 99
            |::...:.|.||::||    .|.|     |....|.|||:|:||:...||..|.|.:.|....||
Human    30 EVAQPEVDTTLGRVRG----RQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDA 90

  Fly   100 TFDGPKCPQ--------LGLVSG-----DVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGF 151
            :...|.|.|        ..:::|     .||||||.:|:|:   |:|......|||:|::|.|..
Human    91 STAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYS---PAEVPAGSGRPVMVWVHGGAL 152

  Fly   152 YSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISR 216
              ::|.:.::.|........:|:||..||||.|||.:||...||||.|..|.|..||||:.:|:.
Human   153 --ITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAP 215

  Fly   217 FGGDPSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLH 281
            ||||.:.:|:.|..||...::..::||::.||||:||..||.:|....:..|...:|.|.|..|.
Human   216 FGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLA 280

  Fly   282 CHTENVTEMMDCLKGKHYLEFA------NTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPI 340
            |.:.:..||:.||:.|...|..      ||:         .||.: ...:.|...:| .|.|:|
Human   281 CSSSSPAEMVQCLQQKEGEELVLSKKLKNTI---------YPLTV-DGTVFPKSPKE-LLKEKP- 333

  Fly   341 RSYQNDDFMKVPIITGMTKDEF---VGPALSILQ-------------SPTLLSALNENFESLAPV 389
                   |..||.:.|:...||   :.....:|.             |..:|::|:...|.:..|
Human   334 -------FHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTV 391

  Fly   390 F--FMYNTSDARA-CNISQELRNHYFPDKLIDANRSLEALSNLYSDALTGFGIHRFVHLAARSTK 451
            .  ::.:.|||:| |...||.....|      .|....:.|....|:               .:.
Human   392 IDEYLGSNSDAQAKCQAFQEFMGDVF------INVPTVSFSRYLRDS---------------GSP 435

  Fly   452 VYYYRFSYQGARSHIYYPEDAPYGVV--HHDDLMYLFVEPSI----SRM-FTEDDDEFRMVDI-M 508
            |::|.|.::.:.    :.:..|..|.  |..:..::|..|.:    ||: |.|..:|.:.:.: |
Human   436 VFFYEFQHRPSS----FAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTM 496

  Fly   509 VRMFSAFAYKGDPNKPTDLALRDIRWRPFSFKKRYYLDIGKHITLEENLNAENYEIWKRLFP--- 570
            :..::.||..||||..   ||..  |..|: :...||:|.......:.......:.|....|
Human   497 MAQWTHFARTGDPNSK---ALPP--WPQFN-QAEQYLEINPVPRAGQKFREAWMQFWSETLPSKI 555

  Fly   571 LNWRRQTK 578
            ..|.::.|
Human   556 QQWHQKQK 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	42..565	CDD:395084	158/573 (28%)
CES3	NP_079198.2	COesterase	32..547	CDD:395084	158/573 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571