DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4382 and Ces2e

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001157228.1	Gene:	Ces2e / 234673	MGIID:	2443170	Length:	559	Species:	Mus musculus

Alignment Length:	611	Identity:	170/611 - (27%)
Similarity:	257/611 - (42%)	Gaps:	127/611 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CGFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGTIL-PSQSGRNFYA 68
            || ||||.....||           |...||.:          |..|::||::: ...:....:.
Mouse    15 CG-VLLLVLHVQGQ-----------DSASPIRN----------THTGQVRGSLVHVKDTDIAVHT 57

  Fly    69 FRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQLGLVSG--------------DVSED 119
            |.|||:|||||..|||.|||..|.|....|.|.....|.|...:.|              .:|||
Mouse    58 FLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLMGSEDLKMMNLILPPISMSED 122

  Fly   120 CLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSL 184
            ||.:|||   :|:.:......||:|:|| ||..:: |.:..:.|........:|:|...||||.|
Mouse   123 CLYLNIY---VPAHAHEGSNLPVMVWIH-GGALTV-GMASMYDGSMLAATEDVVVVAIQYRLGVL 182

  Fly   185 GFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGLF 249
            ||.:||.:.|.||.|..|||..||||:.:|..|||:|..:|:.|..||..:|:.|:|||||:|||
Mouse   183 GFFSTGDQHAKGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLF 247

  Fly   250 HKAIVMSGAVTGQWSLPDHQMDVATKQATLLH--------CHTENVTEMMDCLKGKHYLEFANTL 306
            |.||:.||...    ||    |:.:..:.::|        |...|...:|.||:||:..|.. .:
Mouse   248 HGAIMESGVAV----LP----DLISSSSEMVHRIVANLSGCAAVNSETLMCCLRGKNEAEML-AI 303

  Fly   307 PKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEF-------VG 364
            .|:|:             |.|......||.:.|.....:.||..||.|.|:..||:       :.
Mouse   304 NKVFK-------------IIPGVVDGEFLPKHPQELMASKDFHPVPSIIGINNDEYGWILPTIMD 355

  Fly   365 PAL-----------SILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHYFPDKLID 418
            ||.           ::|:|..|...|......|....:|.:|.|               |:.|..
Mouse   356 PAQKIEEITRKTLPAVLKSTALKMMLPPECGDLLMEEYMGDTED---------------PETLQA 405

  Fly   419 ANRSLEALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSYQGARSHIYYPEDAPYGVVHHDDLM 483
            ..|.::........||      :..|.......||:|.|.::.:....:.|   ||....|.|.:
Mouse   406 QFREMKGDFMFVIPAL------QVAHFQRSHAPVYFYEFQHRPSFFKDFRP---PYVKADHGDEI 461

  Fly   484 YL---FVEPSISRMFTEDDDEF-RMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRPFSFKKRYY 544
            :|   :...:|...:||::::. |.:   ::.::.||..|:||.      ..:.:.|.......|
Mouse   462 FLVFGYQFGNIKLPYTEEEEQLSRRI---MKYWANFARHGNPNS------EGLPYWPVMDHDEQY 517

  Fly   545 LDIGKHITLEENLNAENYEIWKRLFP 570
            |.:....::...|.|...:.|.:..|
Mouse   518 LQLDIQPSVGRALKARRLQFWTKTLP 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	157/568 (28%)
Ces2e	NP_001157228.1	COesterase	30..538	CDD:278561	159/577 (28%)
Ces2e	NP_001157228.1	Aes	<128..>231	CDD:223730	42/107 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832692
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890