Protein Alignment CG4382 and NLGN1

DIOPT Version :9

• Sequence 1: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 677
• Identity: 184/677 - (27%)
• Similarity: 282/677 - (41%)
• Gaps: 164/677 - (24%)

  Fly     1 MWR---LC------GFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGT 56
            :||   .|      |..|.||.|.....:...||:.: |:.||:          :.|..|||||
Human    12 VWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKL-DDVDPL----------VATNFGKIRG- 64

  Fly    57 ILPSQSGRNFYA----FRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ--------- 108
             :..:.......    |.|:|||.||....|||||||...|.|..:||...|.|||
Human    65 -IKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPE 128

  Fly   109 ----------LGLVSG---DVSEDCLRVNIYTKELPSESQP------------------NVR--- 139
                      |.:||.   |.|||||.:|||   :|:|..|                  ::|
Human   129 VMLPVWFTNNLDVVSSYVQDQSEDCLYLNIY---VPTEDGPLTKKQTDDLGDNDGAEDEDIRDSG 190

  Fly   140 --RPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKD 202
              :||:|:|| ||.| :.|....:.|........::::|.|||||.||||:||.:.|.||.||.|
Human   191 GPKPVMVYIH-GGSY-MEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLD 253

  Fly   203 QVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMS---------RGLFHKAIVMSGA 258
            .:|.|||...:|..|||||..||:.|.|||...|.|..:|..|         :|||.:||..||.
Human   254 LIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGT 318

  Fly   259 VTGQWSLPDHQMDVATKQATLLHCHTENVTEMMDCLKGKHYLEFA--NTLPKMFEFDRNNPLILW 321
            ....|::.......|...||.:.|:..:..|:::||:.|.|.|..  :..|..:.       |.:
Human   319 ALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYH-------IAF 376

  Fly   322 KPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEFVGPALSILQSPTLLSALNENFESL 386
            .|||:.|     .:.::|....:..:|:...|:.|:.:.|.:....:|:.|...:||.:.:|.
Human   377 GPVIDGD-----VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFA-- 434

  Fly   387 APVFFMYNTSDARACNISQELRNHY-FPDKLIDANRSLEALSNLYSD-------------ALTGF 437
                            :|..:.|.| :|:.. |..|  |.:..:|:|             .|..|
Human   435 ----------------VSNFVDNLYGYPEGK-DVLR--ETIKFMYTDWADRHNPETRRKTLLALF 480

  Fly   438 GIHRFVHLAARS--------TKVYYYRFSYQGARSHIYYPEDAPYGVVHHDDLMYLFVEPSISRM 494
            ..|::|..|..:        :..|:|.|.:......:....||.:|    |::.|:...|.|...
Human   481 TDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHG----DEVPYVLGIPMIGPT 541

  Fly   495 ------FTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDL----------ALRDIRWRPFSFKKRY 543
                  |:::|  ..:..:::..::.||..||||:|...          ...::.|..:|.|.:.
Human   542 ELFPCNFSKND--VMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQL 604

  Fly   544 YLDIGKHITLEENLNAENYEIWKRLFP 570
            ||.||....::|:..|....:|..|.|
Human   605 YLHIGLKPRVKEHYRANKVNLWLELVP 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	168/621 (27%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	169/628 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142653
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740