Protein Alignment CG4382 and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 169/622 - (27%)
• Similarity: 262/622 - (42%)
• Gaps: 149/622 - (23%)

  Fly    45 VITTALGKIRG--TILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCP 107
            |:.|..|||:|  |.|||:.......:.|:|||.||....||||||....|....:||.....||
Human    47 VVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCP 111

  Fly   108 Q----------------------LGLVSGDVSEDCLRVNIYTKELPSESQPNVRR---------- 140
            |                      |.....|.:||||.:|||   :|.|...|::|
Human   112 QHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIY---VPMEDGTNIKRNADDITSNDH 173

  Fly   141 -------------PVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTR 192
                         ||:|:|| ||.| :.|......|........::::|.|||||.||||:||.:
Human   174 GEDKDIHEQNSKKPVMVYIH-GGSY-MEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQ 236

  Fly   193 EAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSG 257
            .|.||.||.||:|.|||::.::..|||||..:|:.|.||||..|:|..:|..|.|||.|||:.||
Human   237 AAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSG 301

  Fly   258 AVTGQWSLPDHQMDVATKQATLLHCHTENVTEMMDCLKGKHYLEF--ANTLPKMFEFDRNNPLIL 320
            .....|::...........|..:.|:..:.|:|::|||.|:|.|.  ....|..:.       |.
Human   302 TALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLKNKNYKELIQQTITPATYH-------IA 359

  Fly   321 WKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEFVGPALSILQSPTLLSALNENFES 385
            :.|||:.|     .:.::|....:..:|:...|:.|:.:.|.:          ..:..:.:|.:.
Human   360 FGPVIDGD-----VIPDDPQILMEQGEFLNYDIMLGVNQGEGL----------KFVDGIVDNEDG 409

  Fly   386 LAPVFFMYNTSDARACNISQELRNHYFPDKLI------DANRSLEALSNLYSD------------ 432
            :.|..|.::.|:              |.|.|.      |..|  |.:..:|:|
Human   410 VTPNDFDFSVSN--------------FVDNLYGYPEGKDTLR--ETIKFMYTDWADKENPETRRK 458

  Fly   433 ---ALTGFGIHRFVHLAARS--------TKVYYYRFSYQGARSHI--YYPEDAPYGVVHHDDLMY 484
               ||  |..|::|..|..:        :..|:|.| |...:|.:  .:.:.|     |.|::.|
Human   459 TLVAL--FTDHQWVAPAVATADLHAQYGSPTYFYAF-YHHCQSEMKPSWADSA-----HGDEVPY 515

  Fly   485 LFVEPSI------SRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDL----------ALRDIR 533
            :|..|.|      |..|:::|  ..:..:::..::.||..||||:|...          ...::.
Human   516 VFGIPMIGPTELFSCNFSKND--VMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVA 578

  Fly   534 WRPFSFKKRYYLDIGKHITLEENLNAENYEIWKRLFP 570
            |..::.|.:.||.||....:.::..|.....|..|.|
Human   579 WSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVP 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	42..565	CDD:395084	166/615 (27%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	166/615 (27%)