Protein Alignment CG4382 and CES5A

DIOPT Version :9

• Sequence 1: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 174/630 - (27%)
• Similarity: 266/630 - (42%)
• Gaps: 136/630 - (21%)

  Fly     1 MWRLC----------GFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRG 55
            |||||          ...:|...:.:..:.||.     |..|.|..:          |.||.|:|
Human    22 MWRLCLVYYFYPASSTLYVLRIDVLNYTSKDEG-----PSAEGPQRN----------TRLGWIQG 71

  Fly    56 ---TILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKC----------- 106
               |:|.|....|  .|.|:|:|.||:..|||..|:|...|.:..:||.....|
Human    72 KQVTVLGSPVPVN--VFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQ 134

  Fly   107 -------PQLGLVSGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGP 164
                   |:.|     ||||||.:|||.   |:.:....:.||:|:. |||.:. :|.:..|.|.
Human   135 HMLKVHYPKFG-----VSEDCLYLNIYA---PAHADTGSKLPVLVWF-PGGAFK-TGSASIFDGS 189

  Fly   165 QYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGY 229
            .......:::|...||||..||..|..:.||||...||||..|.||:.:|..|||||||:|:.|.
Human   190 ALAAYEDVLVVVVQYRLGIFGFFTTWDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGE 254

  Fly   230 GAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTENVTE---MM 291
            .|||::|:..::|||::|||||||:.||.....: |..|..:.:.....:.|....|.::   ::
Human   255 SAGAISVSSLILSPMAKGLFHKAIMESGVAIIPY-LEAHDYEKSEDLQVVAHFCGNNASDSEALL 318

  Fly   292 DCLKGKHYLEFANTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITG 356
            .||:.|...|......|...|.|         |::     ..|...||:.......|..:|.|.|
Human   319 RCLRTKPSKELLTLSQKTKSFTR---------VVD-----GAFFPNEPLDLLSQKAFKAIPSIIG 369

  Fly   357 MTKDEFVGPALSILQSPTLLSALN--------ENFESLAPVFFMYNTSDARACNISQELRNHYFP 413
            :...| .|..|.:.::|.:||..|        :|...:.|.:.             ..:.|.||.
Human   370 VNNHE-CGFLLPMKEAPEILSGSNKSLALHLIQNILHIPPQYL-------------HLVANEYFH 420

  Fly   414 DKLIDANRSL----EALSNLYSD------ALTGFGIHRFVHLAARSTKVYYYRFSYQGARSHIYY 468
            ||     .||    ::|.:|..|      ||.....||     .....||:|.|.:   |...:
Human   421 DK-----HSLTEIRDSLLDLLGDVFFVVPALITARYHR-----DAGAPVYFYEFRH---RPQCF- 471

  Fly   469 PEDAPYGVV---HHDDLMYLFVEPSISR---MFTEDDDEFRMVD-IMVRMFSAFAYKGDPNKPTD 526
             ||.....|   |.|::.::|....:..   ||....:|.:::. .|::.::.||..|:|| ..|
Human   472 -EDTKPAFVKADHADEVRFVFGGAFLKGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPN-GND 534

  Fly   527 LALRDIRWRPFSFKKRYYLDIGKHITLEENLNAENYEIWKRLFPL 571
            |:|    |..::..:: ||.:..:::|.:.|.....:.|....||
Human   535 LSL----WPAYNLTEQ-YLQLDLNMSLGQRLKEPRVDFWTSTIPL 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	160/572 (28%)
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	162/583 (28%)
		Aes	<155..>258	CDD:223730	42/107 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142611
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840