DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4382 and Ces2e

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	173/596 - (29%)
Similarity:	262/596 - (43%)	Gaps:	94/596 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRLCGFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGT---ILPSQS 62
            :|   |.:||.|.: .||           |...||.:          |..|::||:   :..::|
  Rat    14 VW---GLLLLFCQV-QGQ-----------DSASPIRN----------THTGQVRGSFVHVKDTKS 53

  Fly    63 GRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ----LGL-----------V 112
            |  .:.|.|||:||||:..|||.||||.|.|....|.|.....|.|    |.|           |
  Rat    54 G--VHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENLKIKMSRSPV 116

  Fly   113 SGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTF 177
            |  :|||||.::|||   |:.:..:...||:|:||.||.  ..|.:..:.|........:|:||.
  Rat   117 S--MSEDCLYLSIYT---PAHTHKDSNLPVMVWIHGGGL--CWGMASTYDGSMLAAIEDVVVVTI 174

  Fly   178 NYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVS 242
            .||||.|||.:||...|.||.|..|||..||||:.:|..|||:|..:|:.|..||.::|:.|:||
  Rat   175 QYRLGILGFFSTGDEHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVS 239

  Fly   243 PMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTENVTEMMDCLKGKHYLEFANTLP 307
            |||:||||.||:.||.......:.:....:.|..|.|..|...:...:|.||:.|...|....
  Rat   240 PMSQGLFHGAIMESGVALLPNLISNTSEVIYTMVANLSGCEPVDSEALMSCLREKSEEEMLAI-- 302

  Fly   308 KMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEFVGPALSILQS 372
                   ||.:.....|::     .:||...|:....:.||..||.|.|:..||: |..:.:|..
  Rat   303 -------NNIVRTISGVVD-----GKFLPRHPLELLASVDFHPVPSIIGINSDEY-GWIIPMLHP 354

  Fly   373 PTLLSALNENFESLAPVFFMYNTSDARAC--NISQELRNHYFPDKLIDANRSLEALSN-LYSDAL 434
            .:.:..:|.  |::..|  :.||:.....  ..|..|...|..|  .:.:::|:...| :..|.:
  Rat   355 DSTMKEINR--ETMRAV--LKNTAVQMMLPPECSDLLMEEYMGD--TEDSKTLQIQFNEMMGDFI 413

  Fly   435 TGFGIHRFVHLAARSTKVYYYRFSYQGARSHIYYPEDAPYGVVHHDD-----LMYLFVEPSISRM 494
            ......:..|.......||:|.|.:|   |:.......|:....|.|     :.|||.:  :..:
  Rat   414 FVIPALQVAHFQRSHAPVYFYEFQHQ---SNFLKDIRPPHVKADHGDELPYVIGYLFWD--MKFV 473

  Fly   495 FTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRPFSFKKRYYLDIGKHITLEENLNA 559
            |||  :|..:...|::.::.||..|:||.      ..:.:.|.......||.:.....:...|.|
  Rat   474 FTE--EEKLLSRKMIKYWANFARHGNPNS------EGLPYWPALDHDEQYLQLDIQPVVGRALKA 530

  Fly   560 ENYEIWKRLFP 570
            ...:.|.:..|
  Rat   531 RRLKFWTKTLP 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	161/549 (29%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	163/558 (29%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	44/107 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336313
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.890