DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and cest-28

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_504691.2	Gene:	cest-28 / 187305	WormBaseID:	WBGene00019654	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	609	Identity:	155/609 - (25%)
Similarity:	233/609 - (38%)	Gaps:	184/609 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 KIRGTILPSQSGRNFY--------AFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ 108
            |:..|..|.|.  |.|        .:.|||:|||.|   ||:.|||...|.:..|.|..||:|||
Worm    16 KLNATCGPIQG--NVYRIGDKTVDGYLGIPFAKPLV---RFKKPEPAGTWEEVRDCTKYGPRCPQ 75

  Fly   109 LG-------LVSGDVSED--CLRVNIYTKELPSESQPNVRRPVIVFIHPGGF----------YSL 154
            .|       ....|:.::  ||.:|:::| :......|..|||:|:||.||:          ||:
Worm    76 SGPFAEAINFQKDDIPDEANCLTLNVFSK-ISDSKNFNKTRPVMVYIHGGGYECSASRDYCDYSV 139

  Fly   155 SGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGG 219
            :|.         ...:.:|:||.|||:|.|||..||....|||..|.|....|.|::.||..|||
Worm   140 AGT---------LPLKDVVVVTLNYRVGILGFFTTGDTVCPGNFALWDLTLGLNWIQKHIESFGG 195

  Fly   220 DPSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHT 284
            ||.:||:.|..|||..|.|..:||.||.||::.|||||.     :|.::.:..|..||.:
Worm   196 DPGNITIFGQSAGAACVDLLALSPHSRDLFNRVIVMSGG-----ALCEYAVRTANSQAKV----- 250

  Fly   285 ENVTEMMDCLKGKHYLEFANTLPK-MFEFDRNNPL----------------ILWKPVIEPDFGQE 332
                    |.:...:|.:..|..: :|.:.::.||                :.|.|.::.||..:
Worm   251 --------CYEFARHLGYDGTNSQTLFNWMKSKPLEEIEKMNGFQVPASGILAWTPNLDDDFFPK 307

  Fly   333 --------------------------RFLVEEP------IRSYQNDDFMKVPIITGMTKDEFVGP 365
                                      .||:::|      ::.|.|:.:.|      .|.|.|...
Worm   308 SLDELRIGAPKKDIMMGFAEHEGLFFEFLIKDPTPPLEALKLYVNEYYKK------DTGDHFEAT 366

  Fly   366 ALSILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHYFPDKLIDANRSLEALSNLY 430
            ...|::                  |:..|..|.                   |...:.|.|.:..
Worm   367 RNKIIE------------------FYSRNVEDT-------------------DEKSTKERLIDFV 394

  Fly   431 SDALTGFGI-HRFVHLAARSTKVYYYRFSYQG----ARSHIYYPEDAPYGVVHHDDLMYLFVEPS 490
            .|||...|: ....:.......|:.|.|.|..    .....:....||   .|..||.|:..|..
Worm   395 GDALFTAGVFDNAKNCLKHGNNVWLYIFDYCNPSGFGNQEEFMTFVAP---THCTDLRYVLGEGL 456

  Fly   491 ISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRPFS----------------F 539
            .|. |...::|.:|::.|..::|.||..|:||:.     ....|..|:                .
Worm   457 YSD-FQPTEEEHKMIEKMTTIYSNFAKYGNPNEH-----GSSEWEKFTLDNPRRHFQISYPRGKM 515

  Fly   540 KKRYYLDIGKHITL--EENLNAEN 561
            :..|:.|..|.:.|  .:|.|.||
Worm   516 RNDYHPDRMKFLELIRAKNQNLEN 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	155/609 (25%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	146/583 (25%)
cest-28	NP_504691.2	Aes	<112..>222	CDD:223730	48/118 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820