DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and cest-30

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	578	Identity:	160/578 - (27%)
Similarity:	242/578 - (41%)	Gaps:	118/578 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ELSDLVITTALGKIRGTILPSQSGRNFY-AFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDG 103
            |.:..::....|.|||.|...::|.... .:.|||:||.||..|:|:.|...|:|.:..|....|
Worm    28 EKNSQILNAPCGPIRGNIYKHKNGTKIVDGYLGIPFAKAPVGALKFKKPVAAEKWTEPRDCYEYG 92

  Fly   104 PKCPQLG--------LVSGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGF--------- 151
            |.|||.|        ..:....|:||.:|::.........|. ..||:|:|:.||:
Worm    93 PGCPQTGRFAALTAKSTAAFAEENCLTLNVFAPRWKLAEFPK-GLPVLVYIYGGGYEIGFTSYMD 156

  Fly   152 -YSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHIS 215
             |||:|.         ...:.:::||.|||||.||||......|.||.||.||...|:||:.:|:
Worm   157 DYSLTGT---------LPLKDVIVVTMNYRLGPLGFLTIADGIANGNYGLWDQTLALQWVQDNIA 212

  Fly   216 RFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDV-------- 272
            .|||:|.|:||.|..|||.:.....:||.|..||.::|.|||.....:::....::|
Worm   213 SFGGNPESVTLSGTSAGATSTDFLSLSPHSNQLFQRSISMSGTAFCNFAIRPKDVEVGVCKEFAQ 277

  Fly   273 -----ATKQATLLHCH-TENVTEMMDCLKGKHYLEFANTLPKMFEFDRNNPLILWKPVIEPDFGQ 331
                 .|...:|...: .:||:      |.|....|.:|......|             .|:|..
Worm   278 FQGYTGTDSQSLFDWYMAQNVS------KFKEVAGFQSTAAGAVPF-------------IPNFDG 323

  Fly   332 ERFLVEEPIRSYQNDDFMKVPIITGMTKDEFVGPALSILQSPTLLSALNENFESLAPVFFMYNTS 396
            :.|  .:|....:.:...|..:||.:|. |.||   .|:.:|...:|.| |||......:..:.:
Worm   324 DFF--PKPFDILRREAPKKDALITVVTM-ESVG---MIIFNPLFANAYN-NFEGFINETYGPDVT 381

  Fly   397 DARACNISQELRNHYFPDKLIDANRSLEALSN-----LYSDALTGFGIHRFVHLAARSTKVYYYR 456
            |..| ::.::|...|    |.|.|.|.:|..|     ..||::...|.     |.|..:.|.|..
Worm   382 DYYA-DVKKKLTGFY----LKDVNASDKATVNRRVVDYVSDSVFNSGT-----LDAVKSYVKYGN 436

  Fly   457 FSYQGARSHIYYPEDAPYGVV----------HHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRM 511
            ..|.|:   ..|..||...:|          |..|..|.| ...:...||..|:|..::|:...:
Worm   437 KVYLGS---FNYFNDATKDMVELMQPFKEASHSSDFKYYF-GSGVMANFTPTDEEMEVMDMSGTL 497

  Fly   512 FSAFAYKGDPN-----KPTDLALRDIRWRPFSFKK--RYY-LDIGKHITLEENLNAEN 561
            .:.|...||||     ||         |:|::..|  .|| :|   :.|.|.:.|.:|
Worm   498 MANFVKYGDPNGKSGTKP---------WKPYTILKPNMYYKID---YPTCEMSDNFQN 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	159/577 (28%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	157/569 (28%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	42/117 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157278
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750