DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and ace-1

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_510660.1	Gene:	ace-1 / 181706	WormBaseID:	WBGene00000035	Length:	620	Species:	Caenorhabditis elegans

Alignment Length:	599	Identity:	162/599 - (27%)
Similarity:	262/599 - (43%)	Gaps:	131/599 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ-----LGLVSGD---- 115
            ||:|:....|:|||:|:|||..|||:.|:|.:.|...|:||.....|.|     .|...|.
Worm    36 SQTGKPLTRFQGIPFAEPPVGNLRFKKPKPKQPWRIPLNATTPPNSCIQSEDTYFGDFYGSTMWN 100

  Fly   116 ----VSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVT 176
                :|||||.:|:|   :|.:..||.:..|:|:::.|||:|.:.....:.|....:...::||.
Worm   101 ANTKLSEDCLYLNVY---VPGKVDPNKKLAVMVWVYGGGFWSGTATLDVYDGRILTVEENVILVA 162

  Fly   177 FNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMV 241
            .|||:...|||.....|||||||:.||:..::||..:|..||||.|.|||.|..|||.:|::||:
Worm   163 MNYRVSIFGFLYMNRPEAPGNMGMWDQLLAMKWVHKNIDLFGGDLSRITLFGESAGAASVSIHML 227

  Fly   242 SPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLH----CHTENV-----TEMMDCLKGK 297
            ||.|...||:||:.||:.|..|::  ...|||..:|.:|:    |...::     ..::||.:..
Worm   228 SPKSAPYFHRAIIQSGSATSPWAI--EPRDVALARAVILYNAMKCGNMSLINPDYDRILDCFQRA 290

  Fly   298 HYLEFANTLPKMFEFDRNN---PL-----ILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPII 354
            .    |:.|       |.|   |:     ..|.||::.|     ||:|....|.:..:|.|..::
Worm   291 D----ADAL-------RENEWAPVREFGDFPWVPVVDGD-----FLLENAQTSLKQGNFKKTQLL 339

  Fly   355 TGMTKDEFVGPALSILQSPTLLSALNENFESLAPVFFMYNTSD-------------------ARA 400
            .|..:||.:             ..|......:.||...:..:|                   ...
Worm   340 AGSNRDESI-------------YFLTYQLPDIFPVADFFTKTDFIKDRQLWIKGVKDLLPRQILK 391

  Fly   401 CNIS-QELRNHYFPDKLIDANRS-LEALSNLYSDALTGFGIHRFV----HLAARSTK----VYYY 455
            |.:: ..:.:.|.|..|....|. :.|:..:..|       :.|.    .:|...||    .|||
Worm   392 CQLTLAAVLHEYEPQDLPVTPRDWINAMDKMLGD-------YHFTCSVNEMALAHTKHGGDTYYY 449

  Fly   456 RFSYQGARSHIYYPEDAPYGVVHHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGD 520
            .|:::.::.  .:||  ..||:|..::.::|.||...:.|...|:|..:.:..:|.::.||..||
Worm   450 YFTHRASQQ--TWPE--WMGVLHGYEINFIFGEPLNQKRFNYTDEERELSNRFMRYWANFAKTGD 510

  Fly   521 PNKPTDLALRDIRWRPFSFKKRYYLDIGKHITLEENL----------NAENYEIWKRLFP----- 570
            |||..|.:.....|..::.....|:    ::|:|.:.          ..:....||...|
Worm   511 PNKNEDGSFTQDVWPKYNSVSMEYM----NMTVESSYPSMKRIGHGPRRKECAFWKAYLPNLMAA 571

  Fly   571 --------LNWRRQ 576
                    |.|::|
Worm   572 VADVGDPYLVWKQQ 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	156/573 (27%)
ace-1	NP_510660.1	COesterase	13..561	CDD:278561	156/573 (27%)
ace-1	NP_510660.1	Aes	<114..>249	CDD:223730	56/137 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157329
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4180
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.790