DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4382 and cest-24

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_504613.1	Gene:	cest-24 / 179017	WormBaseID:	WBGene00020891	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	143/533 - (26%)
Similarity:	228/533 - (42%)	Gaps:	104/533 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VITTALGKIRGTILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDG-PKCPQ 108
            ::....|.:.|..:.:..|.....|.|||||:|||..||||.|:|.:.|        :| .||.:
Worm    97 IVRVQQGLLEGFRVKTAKGDLCDVFHGIPYAEPPVGELRFQKPQPPKAW--------EGIRKCNK 153

  Fly   109 L-------------GLVSGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQ--- 157
            .             .|.|.:.|||||.:|::..::..:.    :.||:.:||.||:...|.:
Worm   154 YPNRSIHKEMPWDKALPSANQSEDCLYLNVFAPKIREDK----KYPVLFYIHGGGYVMDSAERYT 214

  Fly   158 SKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPS 222
            :||..  :..::|.:::|||:||||.||||:||....|||.||.|.::.:|||..:||.|||||.
Worm   215 AKNIC--KLLVSREIIVVTFHYRLGFLGFLSTGDDVCPGNYGLFDMLEAMRWVHANISSFGGDPE 277

  Fly   223 SITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDH------------------Q 269
            :|||.|..|||.|..|...||:::|||.:.|||.|.....|:...:                  |
Worm   278 NITLSGQSAGAAAADLLSFSPLTKGLFKRKIVMGGNSYCHWATTSNHDIREYCKKWAKRLGWKPQ 342

  Fly   270 MDVATKQATLLHCHTENVTEMMDCLKG------KHYLEFANTLPKMFEFDRNNPLILWKPVIEPD 328
            ::.|.|:        |...::.:...|      ...:.|:||:.|..:.    ||   .|||:.:
Worm   343 LNYANKR--------EESVDIFNFFNGLPTSKLGMTMFFSNTIFKECQL----PL---APVIDGE 392

  Fly   329 FGQERFLV----EEPIRS------YQNDDFMKVPIITGMTKDEFVGPALSILQSPTLLSALNENF 383
            .......|    :|.:.|      |:...|..:.::.|..|:  :..|:.:|.....||  ....
Worm   393 ILPHDLKVLRETQEHVPSLVGGGEYEALLFCAIGLLRGTEKE--INSAIDVLSRKNRLS--RSKI 453

  Fly   384 ESLAPVFFMYNTSDARACNISQELRNHYFPDKLIDANRSLEALSNLYSDALTGFGIHRFVH-LAA 447
            |::....:    .|:.|.....:.|..:|              ..|.||....:|.:||:. ...
Worm   454 EAMTEKVY----GDSPALRADSKARKMFF--------------VQLISDIFANYGNYRFMRDCQQ 500

  Fly   448 RSTKVYYYRFSYQGARSHIYYPEDAPY-GVVHHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRM 511
            |..:.|.|.|.:|..:...:.....|: |..|..:|.|||....:|.....:..:..:..:....
Worm   501 RGVECYGYSFDHQSKQMWGWLQHVVPFTGGTHTSELSYLFDCNYMSAPLGMNKTDKVVSGMTADY 565

  Fly   512 FSAFAYKGDPNKP 524
            |:.|...|.||.|
Worm   566 FTNFVKFGTPNGP 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	143/533 (27%)
cest-24	NP_504613.1	COesterase	97..608	CDD:278561	143/533 (27%)
cest-24	NP_504613.1	Aes	<183..>285	CDD:223730	43/107 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020