DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and ace-4

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_496962.1	Gene:	ace-4 / 175074	WormBaseID:	WBGene00000038	Length:	602	Species:	Caenorhabditis elegans

Alignment Length:	608	Identity:	157/608 - (25%)
Similarity:	256/608 - (42%)	Gaps:	134/608 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IGSNKELSDLVITTALGKIRGT--ILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTL 97
            |.|.:.:..:|:.|.||.|:||  ...|:..|.|:   |:|:|:|.|:..||:.|...:||....
Worm    18 IDSVQAVHPVVLETKLGDIKGTEFFFLSKKIRTFF---GVPFAEPAVEDFRFRKPREKKQWRGLY 79

  Fly    98 DATFDGPKC-------------PQLGLVSGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPG 149
            |||.....|             .::...:..:|||||.:||:.   |:::   ....|:|:...|
Worm    80 DATKPANACFQTRDNYNTSFWGSEMWNANTQISEDCLYLNIWA---PADA---YNLTVMVWFFGG 138

  Fly   150 GFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHI 214
            ||||.|.....:.|......:.:::|..|||||..|||..|..:|||||||.||...|.||:.:|
Worm   139 GFYSGSPSLSIYDGKALTSTQNVIVVNINYRLGPFGFLYLGHPDAPGNMGLLDQQLALHWVRQNI 203

  Fly   215 SRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSL--PDHQMDVATKQA 277
            ..|||:|..:.:.|..|||.::..|:::|.|||||..||:.||::...|::  |......:.|..
Worm   204 VSFGGNPDKVAVFGQSAGAASIVAHLIAPGSRGLFKNAILQSGSLENTWAINSPFRAKQKSEKLL 268

  Fly   278 TLLHCHTENVTEMMDCLK--------------GKHYLEFANTLPKMFEFDRNNPLILWKPVIEPD 328
            .|:.|:...|...|.||:              ...||||              |.:    ::..|
Worm   269 ELVGCNKTTVDTSMACLRLVSPEQLSLSTWNISLTYLEF--------------PFV----IVSRD 315

  Fly   329 ---FGQERFLVEEPIRSYQNDDFMK-VPIITGMTKDEFVGPALSILQSP-------------TLL 376
               ||.     .:...:.:..||.: |.::.||.|||  |...:|.|.|             |..
Worm   316 KHFFGH-----LDAHAALREGDFNRDVNLMIGMNKDE--GNYWNIYQLPQFFDKADPPELNRTEF 373

  Fly   377 SALNENFESLAP------VFFMYN----TSDAR-----ACNISQELRNHYFP-DK--LIDANRSL 423
            ..|.:...|:.|      ..::|:    |...|     |..::|.:.:::|. |.  |.|..||:
Worm   374 DFLIDRTFSIQPDIIRSAAKYIYSDPNCTDHGRKTRFYAGQMNQIVGDYFFSCDSLWLADQFRSI 438

  Fly   424 EALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSYQGARSHIYYPEDAPYGVVHHDDLMYLFVE 488
            ..:.:.......|              ||:.|.|:...:.:    |.....|.:|..::.|:|..
Worm   439 PRVKSSSPQRKPG--------------KVFVYHFTQSSSAN----PWPKWTGAMHGYEIEYVFGI 485

  Fly   489 P-SISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIR----WRPFSFKKRY---YL 545
            | |.|:.:...:..|...  :::.:::||..|.|.      ||.::    |..|:.:..|   .|
Worm   486 PLSYSKNYKRREQIFSRK--IMQFWASFAKNGTPK------LRVLKNSEHWPEFNEQNHYRWMQL 542

  Fly   546 DIGKHITLEENLNAENYEIWKRL 568
            ..|.:|...:.......:.|:|:
Worm   543 RSGSNIRPIKPKKQVECQFWRRV 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	153/597 (26%)
ace-4	NP_496962.1	COesterase	28..562	CDD:278561	153/593 (26%)
ace-4	NP_496962.1	Aes	<120..>243	CDD:223730	50/128 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840