Protein Alignment CG4382 and AADACL3

DIOPT Version :10

• Sequence 1: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001096640.2
• Gene: AADACL3 / 126767
• HGNCID: 32037
• Length: 407
• Species: Homo sapiens
• Alignment Length: 430
• Identity: 81/430 - (18%)
• Similarity: 137/430 - (31%)
• Gaps: 141/430 - (32%)

  Fly    77 PPVDRLRFQPPEPVEQW-FDTLDATFDGPKCPQLGLVSGDVSEDCLRVNIYTKELPSESQPNVRR 140
            ||   |::.|...|..: |.|:......||.....|                            :
Human    79 PP---LKYDPDVVVTDFRFGTIPVKLYQPKASTCTL----------------------------K 112

  Fly   141 PVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGN---MGLKD 202
            |.||:.|.||  .:.|..|...|    :..||.      :......||.|.|:.|.:   :.::|
Human   113 PGIVYYHGGG--GVMGSLKTHHG----ICSRLC------KESDSVVLAVGYRKLPKHKFPVPVRD 165

  Fly   203 -QVQLLRWVKLHISRFGGDPSSITLLG--YGAGAMAVTLHMV-----SPMSRGLFHKAIVMSGAV 259
             .|..:.::| .:..:|.||:.:.:.|  :|....||....:     .|..|     |.::..|:
Human   166 CLVATIHFLK-SLDAYGVDPARVVVCGDSFGGAIAAVVCQQLVDRPDLPRIR-----AQILIYAI 224

  Fly   260 TGQWSL--PDHQMDVATKQATLLHCHTENVTEMMDCLKGKHYLEFANTLPKMFEFDRNNPLILWK 322
            .....|  |..|.   .|...||       |....|......|:|:::..::.....:.|..:|:
Human   225 LQALDLQTPSFQQ---RKNIPLL-------TWSFICYFFFQNLDFSSSWQEVIMKGAHLPAEVWE 279

  Fly   323 -------PVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMTKDEFVGPALSILQSPTLLSALN 380
                   |...|:..:||....:|........:::|.::            |.::.||.:   ..
Human   280 KYRKWLGPENIPERFKERGYQLKPHEPMNEAAYLEVSVV------------LDVMCSPLI---AE 329

  Fly   381 ENFESLAPVFFMYNTSDARACNISQELRNHYFPDKLIDANRSLEALSNLYSDALTGFGIHRFVHL 445
            ::..|..|          ..|.:|.|.      |.|.|.       |.||...|...|:....|
Human   330 DDIVSQLP----------ETCIVSCEY------DALRDN-------SLLYKKRLEDLGVPVTWH- 370

  Fly   446 AARSTKVYYYRFSYQGARSHIYYPEDAPYGVVHHDDLMYL 485
                                  :.||..:||:...|:.:|
Human   371 ----------------------HMEDGFHGVLRTIDMSFL 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	42..565	CDD:395084	81/430 (19%)
AADACL3	NP_001096640.2	Abhydrolase_3	115..378	CDD:400284	66/351 (19%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	119..121		1/1 (100%)