Protein Alignment CG4382 and CES1

DIOPT Version :10

• Sequence 1: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 166/575 - (28%)
• Similarity: 263/575 - (45%)
• Gaps: 98/575 - (17%)

  Fly    45 VITTALGKIRGTILPSQS-GRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKC-- 106
            |:.|..||:.|..:..:. .:....|.|||:||||:..|||.||:|.|.|....:||...|.|
Human    26 VVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQ 90

  Fly   107 -PQLGLVSGD------------VSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQS 158
             |:.|.:..:            :|||||.:||||   |::.....|.||:|:||.||.  :.|.:
Human    91 DPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYT---PADLTKKNRLPVMVWIHGGGL--MVGAA 150

  Fly   159 KNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSS 223
            ..:.|.....:..:|:||..||||..||.:||...:.||.|..|||..||||:.:|:.|||:|.|
Human   151 STYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGS 215

  Fly   224 ITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSG-AVTGQWSLPDHQMDVATKQATLLHCHTENV 287
            :|:.|..||..:|::.::||:::.|||:||..|| |:|...........:|.:.|....|.|...
Human   216 VTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTS 280

  Fly   288 TEMMDCLKGKHYLEFANTLPKM------FEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQND 346
            ..|:.||:.|...|...|..||      .:.|......|...||:   |.......|.:::.:|
Human   281 AVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVID---GMLLLKTPEELQAERN- 341

  Fly   347 DFMKVPIITGMTKDEF--------VGPALS--ILQSPTLLSALNENFESLAPVFFMYNTSDARAC 401
             |..||.:.|:.|.||        :...||  .|...|.:|.|.:::    |:          .|
Human   342 -FHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSY----PL----------VC 391

  Fly   402 NISQELRNHYFP---DKLI----DANRSLEALSNLYSDALTGFGIHRFVHLAARSTK-----VYY 454
             |::||    .|   :|.:    |..:..:...:|.:|.:  ||:...:  .||:.:     .|.
Human   392 -IAKEL----IPEATEKYLGGTDDTVKKKDLFLDLIADVM--FGVPSVI--VARNHRDAGAPTYM 447

  Fly   455 YRFSYQGARSHIYYPEDAPYGVV--HHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAY 517
            |.|.|:.:    :..:..|..|:  |.|:|..:|..|.:....:|  :|.|:..::::.::.||.
Human   448 YEFQYRPS----FSSDMKPKTVIGDHGDELFSVFGAPFLKEGASE--EEIRLSKMVMKFWANFAR 506

  Fly   518 KGDPN---KPTDLALRDIRWRPFSFKKRYYLDIGKHITLEENLNAENYEIWKRLF 569
            .|:||   .|        .|..:: :|..||.||.:....:.|..:....|..||
Human   507 NGNPNGEGLP--------HWPEYN-QKEGYLQIGANTQAAQKLKDKEVAFWTNLF 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	42..565	CDD:395084	163/569 (29%)
CES1	NP_001020366.1	COesterase	23..548	CDD:395084	163/569 (29%)