Protein Alignment CG4382 and CEL

DIOPT Version :10

• Sequence 1: NP_609301.2
• Gene: CG4382 / 34279
• FlyBaseID: FBgn0032132
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 159/570 - (27%)
• Similarity: 242/570 - (42%)
• Gaps: 102/570 - (17%)

  Fly    36 GSNKELSDLVITTALGKIRGTILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDAT 100
            |.||:|..|                  |.:...|:|||:|.|   ....:.|:|...|..||.|.
Human    35 GVNKKLGLL------------------GDSVDIFKGIPFAAP---TKALENPQPHPGWQGTLKAK 78

  Fly   101 FDGPKCPQLGLVS----GDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNF 161
            ....:|.|..:..    ||  ||||.:||:..:  ...|.:...||:::|:.|.|...||...||
Human    79 NFKKRCLQATITQDSTYGD--EDCLYLNIWVPQ--GRKQVSRDLPVMIWIYGGAFLMGSGHGANF 139

  Fly   162 A------GPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGD 220
            .      |.:......:::||||||:|.||||:||....|||.||:||...:.|||.:|:.||||
Human   140 LNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGD 204

  Fly   221 PSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTE 285
            |::|||.|..||..:|:|..:||.::||..:||..||.....|.:..:.:..|.|.|..:.|...
Human   205 PNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVG 269

  Fly   286 NVTEMMDCLKGKHYLEFANTLPKMFEFDRNNPL----------ILWKPVIEPDFGQERFLVEEPI 340
            :...|..|||        .|.|:........||          :.:.|||:.|     |:..:||
Human   270 DAARMAQCLK--------VTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGD-----FIPADPI 321

  Fly   341 RSYQNDDFMKVPIITGMTKDEFVGPALSILQSPTL----LSALNENFESLAPVFFMYNTSDARAC 401
            ..|.|  ...:..|.|....:  |...:.:..|.:    .....|:|..|...|.:  |...|..
Human   322 NLYAN--AADIDYIAGTNNMD--GHIFASIDMPAINKGNKKVTEEDFYKLVSEFTI--TKGLRGA 380

  Fly   402 NISQELRNHYFPDKLIDANRSLEALSNLYSDALTGFGIHRFVHLA-----ARSTKVYYYRFSYQG 461
            ..:.::....:.......|:. :.:.:..:|.|  |.:...:.||     |:|.|.|.|.||:.
Human   381 KTTFDVYTESWAQDPSQENKK-KTVVDFETDVL--FLVPTEIALAQHRANAKSAKTYAYLFSHP- 441

  Fly   462 ARSHIYYPEDAP--YGVVHHDDLMYLFVEPSISRMFTEDDDEFRMVD-IMVRMFSAFAYKGDPNK 523
            :|..:|     |  .|..|.||:.|:|.:|..:.......|  |.|. .|:..::.||..||||.
Human   442 SRMPVY-----PKWVGADHADDIQYVFGKPFATPTGYRPQD--RTVSKAMIAYWTNFAKTGDPNM 499

  Fly   524 -----PTDLALRDIRWRPFSFKKRYYLDIGKHI---TLEENLNAENYEIW 565
                 ||       .|.|::.:...||:|.|.:   :::.:|.......|
Human   500 GDSAVPT-------HWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYW 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	42..565	CDD:395084	154/562 (27%)
CEL	NP_001798.3	Heparin-binding	21..121		30/110 (27%)
		COesterase	26..542	CDD:395084	158/568 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
		Mucin-like	584..677	CDD:464997
		Mucin-like	639..731	CDD:464997