DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4382 and Ces1f

DIOPT Version :9

Sequence 1:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	166/563 - (29%)
Similarity:	243/563 - (43%)	Gaps:	78/563 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VITTALGKIRGTILPSQSG--RNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCP 107
            |:.|..||:.|..: |..|  ::...|.|:|:||||:..|||.||:|.|.|....:.|...|.|.
  Rat    25 VVDTTKGKVLGKYV-SLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCS 88

  Fly   108 Q---LGLVSGDV------------SEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQ 157
            |   .|....|:            |||||.:||||   |::...|.|.||:|:||.||. :|.|.
  Rat    89 QDAAKGQRMNDLLTNRKEKIHLEFSEDCLYLNIYT---PADFTKNSRLPVMVWIHGGGM-TLGGA 149

  Fly   158 SKNFAGPQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPS 222
            | .:.|........:|:|...||||..||.:||...:.||.|..|||..|.||:.:|:.|||||.
  Rat   150 S-TYDGRVLSAYENVVVVAIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPG 213

  Fly   223 SITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTENV 287
            |:|:.|..||..:|::.::||:::.|||:||..||.|.....|.......|.:.|.:..|.|...
  Rat   214 SVTIFGESAGGFSVSVLVLSPLTKNLFHRAISESGVVFLPGLLTKDVRPAAKQIADMAGCETTTS 278

  Fly   288 TEMMDCLKGKHYLEFANTLPKM------FEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQND 346
            ..::.||:.|...|....:.||      .:.|..........|::     ...|.::|.......
  Rat   279 AIIVHCLRQKTEEELLEIMKKMNLIKLSSQRDNKESYHFLSTVVD-----NVVLPKDPKEILAEK 338

  Fly   347 DFMKVPIITGMTKDE----------FVGPALSILQSPTLLSALNENFESLAPVFFMYNTSDARAC 401
            :|..||.|.|:.|.|          || ||...|.....::.| |.|.||..:     ..|....
  Rat   339 NFNTVPYIVGINKQECGWLLPTMMGFV-PADVELDKKMAITLL-EKFASLYGI-----PEDIIPV 396

  Fly   402 NISQELRNHYFPDKLIDANRSLEALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSYQGARSHI 466
            .|.:..:.   .|..|.....:.|.....|.::....:.|....|...|.:|.|:
  Rat   397 AIEKYRKG---SDDSIKIRDGILAFIGDVSFSIPSVMVSRDHRDAGAPTYMYEYQ---------- 448

  Fly   467 YYPE----DAPYGVV--HHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPT 525
            |||.    ..|..||  |.|||..:|..|.:....:|  :|.::..::::.::.||..|:||.
  Rat   449 YYPSFSSPQRPKHVVGDHADDLYSVFGAPILRDGASE--EEIKLSKMVMKFWANFARNGNPNG-- 509

  Fly   526 DLALRDIRWRPFSFKKRYYLDIGKHITLEENLNAENYEIWKRL 568
                |.:...|...:|..||.||......:.|.||....|.:|
  Rat   510 ----RGLPHWPQYDQKEEYLQIGATTQQSQRLKAEEVAFWTQL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	164/558 (29%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	164/558 (29%)
		Aes	<121..>234	CDD:223730	48/117 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336535
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.900