Protein Alignment CG3841 and TG

DIOPT Version :10

• Sequence 1: NP_609300.1
• Gene: CG3841 / 34278
• FlyBaseID: FBgn0032131
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_003226.4
• Gene: TG / 7038
• HGNCID: 11764
• Length: 2768
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 155/641 - (24%)
• Similarity: 253/641 - (39%)
• Gaps: 170/641 - (26%)

  Fly    15 LIGFTTAVTFIGDDPVVELSL-GRIQGDTMQ-SFGN--KTIYAFRGIRYAQSPVGQLRFANPVPE 75
            |:.:..:|      |.|.:|. ||:.|.:.. ..|.  |.:..|.|:.||..|:.:.||..|.|
Human  2191 LLSYEASV------PSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEP- 2248

  Fly    76 TSWGDEVFNATSDSLVCPQPGVVSL----MSEDCLKINVF-TKSFEDKFPVMVYIHGGANVLGSG 135
            .:|... ::|:.....|.|||..:.    :|||||.:||| .::......|:|:.|   |.:...
Human  2249 LNWTGS-WDASKPRASCWQPGTRTSTSPGVSEDCLYLNVFIPQNVAPNASVLVFFH---NTMDRE 2309

  Fly   136 HSSYEAGPQYLLD-------QDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHI 193
            .|  |..|  .:|       .:::.|..:||:|..||||:.|.|..||:|.||||.||.||:.||
Human  2310 ES--EGWP--AIDGSFLAAVGNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHI 2370

  Fly   194 SHFGGDPELVTIIGISAGSMAVSLHL--ASPLSAGLFHRAILMSGSATNHFDIDNLFWTRK---- 252
            ..|||||..|::.....|:...|:||  |...::.||.||:||.|||.:...:.:....::
Human  2371 RGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIA 2435

  Fly   253 LARELGCPMYDPTDVVECLR-------NETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNHPT 310
            ||:|:.|||....:||.|||       |:..|:::.|...:.       .|...||||||...|.
Human  2436 LAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFH-------YWGPVIDGHFLREPPA 2493

  Fly   311 ELIKEGNFNKVPLLISFTANEFDYNANVHLENQHLLHDFASNFVDYAPELFLYR----------H 365
            ..:|...:.:|.|||..:.::...|      ....:..|..:....:.:...|:          .
Human  2494 RALKRSLWVEVDLLIGSSQDDGLIN------RAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDS 2552

  Fly   366 DAQIGEKLKDFYLGDNTTE---INSENIENFGQIFSDAYIGHGVHRLVQLASHFTP-------VY 420
            ||::......:|..:::|:   ..|..:||..:   |.:|   :..::.:||.:..       :|
Human  2553 DARVEAAATWYYSLEHSTDDYASFSRALENATR---DYFI---ICPIIDMASAWAKRARGNVFMY 2611

  Fly   421 YTRMDYVGDQSLSAPLNGENKPVGVGHAD-----DLHYVL-----PGYWYGPLMAANDSDVFMME 475
            :.                   |...||..     |:.:.|     |.|          ...|.:|
Human  2612 HA-------------------PENYGHGSLELLADVQFALGLPFYPAY----------EGQFSLE 2647

  Fly   476 ------RLTSWFTHFAKTGTPLNSTDI----------WPPCNSTVLKMLYNGVVTQVGSPGYS-- 522
                  ::..:|:||.::|.|....:.          ||            ..|.:.|...|.
Human  2648 EKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWP------------DFVPRAGGENYKEF 2700

  Fly   523 -----NRYAV-------WDKLFPT------AAQGGGAALKLSFAVAIATGVASRLI 560
                 ||..:       |.|...:      .|:||.:|......:...:|:...|:
Human  2701 SELLPNRQGLKKADCSFWSKYISSLKTSADGAKGGQSAESEEEELTAGSGLREDLL 2756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_609300.1	COesterase	27..528	CDD:395084	145/589 (25%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:459665
		Thyroglobulin_1	662..724	CDD:459665
		TY	730..>776	CDD:469630
		TY	<892..922	CDD:469630
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:429604
		Type II. /evidence=ECO:0000269|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710	2188..2768		155/641 (24%)
		COesterase	2197..2718	CDD:395084	146/595 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2727..2768		6/30 (20%)