DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3841 and Ces1a

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001177304.1	Gene:	Ces1a / 679817	RGDID:	1583671	Length:	563	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	159/548 - (29%)
Similarity:	247/548 - (45%)	Gaps:	91/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WALLLILIGFTTAVTF--IGDDPVVELSLGRIQGD--TMQSFGNKTIYAFRGIRYAQSPVGQLRF 69
            |...|.|....|.:.|  ....|||:...|::.|.  :::.| .:.:..|.|:.:|:.|:|.|||
  Rat     2 WLFALALTSLNTYMAFGHPSSPPVVDTLQGKVLGKYISLEGF-TQPVAVFLGVPFAKPPLGSLRF 65

  Fly    70 ANPVPETSWGDEVFNATSDSLVCPQ-PGVVSLM---------------SEDCLKINVFTK---SF 115
            |.|.|..|| ..|.||||...:|.| .||..::               |||||.:|:::.   :.
  Rat    66 APPQPAESW-SFVKNATSYPPMCSQITGVGPVLSEVFTNQLENVPLEYSEDCLYLNIYSPTDLTS 129

  Fly   116 EDKFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFL 180
            :|:.||||::||| .:|..|.|::: |......:.||.|...||||..|||||....::||:|..
  Rat   130 KDRLPVMVWVHGG-GLLSGGASTFD-GLALSTHEKVVVVVIQYRLGIWGFLSTGDEHSRGNWGHF 192

  Fly   181 DQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNH--FD 243
            |||.||:||:::|.:|||||..||:.|.|||..:||:.:.|||:..||||||..||.|...  |.
  Rat   193 DQVAALQWVQNNIVNFGGDPNSVTLFGESAGGESVSVLVLSPLTKNLFHRAISESGVALTPCLFR 257

  Fly   244 IDNLFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQL---VNMKWNYE-----I 300
            .:......::|...||......|:|.|||.:|...::......:.:.|   .:.:.:|.     |
  Rat   258 ENTRLAAEQVAIATGCAATTSADIVRCLREKTEEELLATTLKMKFFALDLHGDPRESYPFLTTVI 322

  Fly   301 DGHFLHNHPTELIKEGNFNKVPLLISFTANEFDY------------------NANVHLENQHLLH 347
            ||..|...|.|::.|.|||.||.::.....||.:                  .|...|...:.|.
  Rat   323 DGVLLPKAPEEILSEKNFNTVPYIVGINKQEFGWFIPTMMGYPLSESKLDQKTATSLLWKSYPLT 387

  Fly   348 DFASNFVDYAPELFLYRHDAQIGEKLKDFYL---GDNTTEINSENIENFGQIFSDAYIGHGVHRL 409
            :.:......|.|.:|...|..  :|.||.:|   ||....:.|..:..:             ||.
  Rat   388 NISKELTPVATEKYLGGSDCP--DKKKDLFLDMMGDVLFAVPSVIVARY-------------HRD 437

  Fly   410 VQLASHFTPVYYTRMDYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPLM--AANDSDVF 472
            .:..::.....| ...:|.|.        ..|.|...|.|:::.|    |..|.:  .|::.::.
  Rat   438 ARATTYVYEFKY-HPSFVSDM--------RPKTVIADHGDEVYSV----WGTPFLKEGASEEEIN 489

  Fly   473 MMERLTSWFTHFAKTGTPLNSTDI--WP 498
            :...:..::.:||:.|.| |...:  ||
  Rat   490 LSTMMMKFWGNFARNGNP-NGEGLPHWP 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	154/528 (29%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	57/118 (48%)
Ces1a	NP_001177304.1	COesterase	24..545	CDD:278561	154/526 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336508
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.790