DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3841 and LOC679149

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	173/591 - (29%)
Similarity:	269/591 - (45%)	Gaps:	96/591 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRFFQLTW------ALLLILIGFTTAVTFIG-----DDPVVELSLGRIQG------DTMQSFGN 48
            ||:....:|      .|||:||...      |     ..|:....:|:::|      ||...
  Rat     1 MPQNQLHSWLNAVFFGLLLLLIHVQ------GQHSPESSPIRNTHIGQVRGKLDHVKDTKAG--- 56

  Fly    49 KTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVCPQ-------PGVVSL------ 100
              ::.|.||.:|:.|||.||||.|.....|.. |.:.||...:|.|       .|:..:
  Rat    57 --VHTFLGIPFAKPPVGPLRFAPPEAPEPWSG-VRDGTSQPAMCLQNLDVINAEGLKEMKLKLPP 118

  Fly   101 --MSEDCLKINVFTKSFE---DKFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRL 160
              ||||||.:|::..:..   ...||||:||||.  |.:|.:|...|....:::|:|.|...|||
  Rat   119 VSMSEDCLYLNIYAPAHAHEGSNLPVMVWIHGGG--LMTGMASMYDGSLLTVNEDLVVVTIQYRL 181

  Fly   161 GALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSA 225
            |.|||.||.....:||:|:||||.||.||:.:|:||||:|:.|||.|.|||...||.|:.||:|.
  Rat   182 GVLGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTCVSTHVVSPMSQ 246

  Fly   226 GLFHRAILMSGSATNHF---DIDNLFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWE 287
            ||||.||:.||.|...:   |...:|.| .:|:..||...|...:|.|||.::...|:.:.|..:
  Rat   247 GLFHGAIMESGVALLPYLIADTSEMFST-MVAKVSGCEAMDSEALVHCLRAKSEAEILAINKVVQ 310

  Fly   288 TYQLVNMKWNYEIDGHFLHNHPTELIKEGNFNKVPLLISFTANEFDYNANVHLENQHLLHDFASN 352
            ....|       :||.||..||.||:...:|..||.:|....:|:.:...:.:....::.:.:..
  Rat   311 MVPAV-------VDGEFLPRHPKELLASEDFRPVPSIIGVNNDEYGWTIPLVMGTTQMIKELSRE 368

  Fly   353 FVDYAPELFLYRHDAQI------GEKLKDFYLGD----NTTEIN-SENIENFGQIFSDAYIGHGV 406
            .:    :..|.:..||:      .:.|.:.|:||    .|.:.. :|.:|:|..:.....:.|
  Rat   369 NL----QAILKKTTAQLMLPLECSDLLMEEYMGDIEDPKTLQAQFTELMEDFMFVIPALQVAH-- 427

  Fly   407 HRLVQLASHFTPVYYTRMDYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPLMA-ANDSD 470
                ...|| .|||:    |.....::...:.....|...|.|::.:|. ||::..:.. ..:.:
  Rat   428 ----FQCSH-APVYF----YEFQHQITFLKDIRPPHVKADHGDEIPFVF-GYFFWDMKTDFTEEE 482

  Fly   471 VFMMERLTSWFTHFAKTGTPLNSTDI--WPPCNSTVLKMLYNGVVTQ--VGSPGYSNRYAVWDKL 531
            ..:..|:..::.:||:.|.| ||..:  ||..:.   ...|..:.||  ||....:.|...|.|.
  Rat   483 KLLSRRMMKYWANFARHGNP-NSEGLSYWPVMDH---DQQYLQLDTQPAVGRALKARRLQFWTKT 543

  Fly   532 FPTAAQ 537
            .|...|
  Rat   544 LPQKIQ 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	160/543 (29%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	60/121 (50%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	160/544 (29%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	47/104 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336317
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.800