DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and ces2b

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	566	Identity:	186/566 - (32%)
Similarity:	267/566 - (47%)	Gaps:	96/566 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLILIGFTTAVTFIGDD-PVVELSLGRIQGDTMQSFGNKT-IYAFRGIRYAQSPVGQLRFANPVP 74
            |.|||..|...:...:| |:::.:.|.::|..|::.|..| |:::.||.:|:.|||.||.|.|.|
Zfish    11 LCILIAVTLQNSVKAEDGPILQTNSGALKGLQMKARGKDTVIHSYLGIPFAKPPVGPLRLAPPQP 75

  Fly    75 ETSWGDEVFNATSDSLVCPQPG------VVSL--------MSEDCLKINVFTKS---FEDKFPVM 122
            ...| :.|.:||...|:|.|..      |.:|        .|||||.:||:|.|   ..||.|||
Zfish    76 AEKW-EGVRDATKQPLMCLQDRQLVEDLVANLSAKVDMVDSSEDCLYLNVYTPSKPGRNDKLPVM 139

  Fly   123 VYIHGG-----ANVLGSGH--SSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFL 180
            |:||||     :..|..||  ::|         ||||.|...||||.|||.||......||:|.|
Zfish   140 VWIHGGGFTTCSASLFDGHVLAAY---------QDVVVVVIQYRLGLLGFFSTGDENAPGNYGLL 195

  Fly   181 DQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNH--FD 243
            |||.||:||:::|..|||||..|||.|.|||.::||||:.|||||.||||||..||:|...  .:
Zfish   196 DQVAALQWVQENIHSFGGDPGSVTIFGESAGGISVSLHVLSPLSANLFHRAIAESGTAAMEAIMN 260

  Fly   244 IDNLFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNH 308
            ::.|...:.:....||.:.....:|:||..::...|:::     |.:....::...|||.||...
Zfish   261 VNPLPIAQAIGNASGCDISSTKKIVDCLMQKSEVEILKI-----TMENPLFRFGVTIDGQFLPRP 320

  Fly   309 PTELIKEGNFNKVPLLISFTANEFDYNANVHLENQHLLHDFAS--NFVDYAPELFLYR---HDAQ 368
            ..||.:...||||||:...|.:|..:    .|.|..|..|:.:  :.....|.|.::.   .|..
Zfish   321 AAELFQSQQFNKVPLMTGVTDDEIGF----VLPNYLLPPDWINGLDLESILPLLTVFNPALQDQS 381

  Fly   369 IGEKLKDFYLGDNTTEINSENIENFGQIFSDAYIGHGVHRLVQLASHF----TPVYYTRMDYVGD 429
            :.|.|.:.|||.:...|...  :.|.::..|........   |.||:.    .|||.....:
Zfish   382 VLELLLNEYLGTSPDRIRIR--DGFREMLGDFMFNIPAR---QTASYHRDAGAPVYVYEFRH--- 438

  Fly   430 QSLSAPLNGENKP--VGVGHADDLHYVLPGYWY--GPL-MAAN--DSDVFMMERLTSWFTHFAKT 487
               ...:....:|  .|..|.|::.:|. ||.:  ||: ||.|  |.:..:.....:::.:||.|
Zfish   439 ---PPSVLQRKRPSFSGSDHGDEIVFVF-GYCFSEGPIGMAENLSDEEDELCRTTMAYWGNFAHT 499

  Fly   488 GTP----LNSTDIWP--------------PCNSTVLKMLYNGVVTQ 515
            |.|    |.|   ||              |..||.||..:...|||
Zfish   500 GNPNGPGLTS---WPEFGDEAEYLSIGLDPKASTDLKGKHFTFVTQ 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	181/551 (33%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	67/125 (54%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613	178/545 (33%)
		COesterase	553..1065	CDD:306613
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910