Protein Alignment CG3841 and NLGN3

DIOPT Version :9

• Sequence 1: NP_001188759.1
• Gene: CG3841 / 34278
• FlyBaseID: FBgn0032131
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 657
• Identity: 176/657 - (26%)
• Similarity: 261/657 - (39%)
• Gaps: 186/657 - (28%)

  Fly     9 WALLLILIGFTTAVTFIGDDPVVELSLGRIQGDTM----QSFGNKTIYAFRGIRYAQSPVGQLRF 69
            |.|.|.|...|.|..     |.|....|:::|..:    :..|  .:..:.|:.||..|:|:.||
Human    27 WFLSLALRASTQAPA-----PTVNTHFGKLRGARVPLPSEILG--PVDQYLGVPYAAPPIGEKRF 84

  Fly    70 ANPVPETSWGDEVFNATSDSLVCPQ------PGV----------------VSLMSEDCLKINVFT 112
            ..|.|..||.. :.|||....||||      |.|                :...:||||.:||:.
Human    85 LPPEPPPSWSG-IRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYV 148

  Fly   113 -----------------------------KSFED----------------KFPVMVYIHGGANVL 132
                                         |..||                ..|||||||||:.:.
Human   149 PTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYME 213

  Fly   133 GSGH-------SSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVR 190
            |:|:       :||         .:|:.:..|||:|.||||||.....|||:|.|||:.||.||.
Human   214 GTGNMIDGSILASY---------GNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVS 269

  Fly   191 DHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDID--NLFWTRKL 253
            ::|:.|||||..:|:.|...|:..|||...|..|.|||.|||:.||||.:.:.::  .:.:|..|
Human   270 ENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLL 334

  Fly   254 ARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNHPTELIKEGNF 318
            |.::||.:.|..|:|:|||.::...:||.......|   ::.:...|||..:.:.|..|:::|.|
Human   335 ADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARY---HVAFGPVIDGDVIPDDPEILMEQGEF 396

  Fly   319 NKVPLLISFTANE-------------------FDYNANVHLENQHLLHDFASNFVDYAPELFLYR 364
            ....:::.....|                   |||:              .|||||   .|:.|.
Human   397 LNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYS--------------VSNFVD---NLYGYP 444

  Fly   365 HDAQ-IGEKLKDFYLGDNTTEINSENIE----NFGQIFSDAYIGHGVHRLVQ--------LASHF 416
            .... :.|.:|..|    |...:.:|.|    ....:|:|       |:.|:        .|.:.
Human   445 EGKDTLRETIKFMY----TDWADRDNPETRRKTLVALFTD-------HQWVEPSVVTADLHARYG 498

  Fly   417 TPVYYTRMDYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGP--LMAANDS--DVFMMERL 477
            :|.|:... |...|||..|...:     ..|.|::.||......||  |...|.|  ||.:...:
Human   499 SPTYFYAF-YHHCQSLMKPAWSD-----AAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVV 557

  Fly   478 TSWFTHFAKTGTPLNSTD----------------IWPPCNSTVLKMLYNGVVTQVGSPGYSNRYA 526
            .:::|:|||||.|.....                .|...|......|:.|:..:|.....:.:.|
Human   558 MTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVA 622

  Fly   527 VWDKLFP 533
            .|..|.|
Human   623 FWKHLVP 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	167/632 (26%)
		Aes	<116..>235	CDD:223730	57/141 (40%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	169/641 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142576
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740