DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and Cesl1

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_038953870.1	Gene:	Cesl1 / 501232	RGDID:	1565666	Length:	596	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	176/600 - (29%)
Similarity:	265/600 - (44%)	Gaps:	118/600 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTWALL--------LILIGFTTAVTFIGD---DPVVELSLGRIQGDTMQSFG-NKTIYAFRGIRY 59
            :.|::.        |.|:...|.|. .|:   .|||:...|::.|......| .:::..|.|:.:
  Rat    27 IDWSICPRKMCLRSLFLVSLATCVV-CGNPSSPPVVDTMKGKVLGKYASLEGVTQSVAVFLGVPF 90

  Fly    60 AQSPVGQLRFANPVPETSWGDEVFNATSDSLVCPQPGV---------------VSL-MSEDCLKI 108
            |:.|:|.||||.|.|...| ..|.|.|:...:|.|...               |.| .|||||.:
  Rat    91 AKPPLGSLRFAPPQPAEPW-SFVKNTTTYPPMCSQDATKGQRMNDLLTNRKEKVHLQFSEDCLYL 154

  Fly   109 NVFTK---SFEDKFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNS 170
            |::|.   :.:.:.||||:||||....| |.|:|: |......::||.||..||||..||.||..
  Rat   155 NIYTPADFTKDSRMPVMVWIHGGGLTQG-GASTYD-GQVLSAYENVVVVAIQYRLGIWGFFSTGD 217

  Fly   171 SETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMS 235
            ..::||:|.||||.||.||:|:|::|||||..|||.|.|||..:||:.:.||||..|:||||..|
  Rat   218 EHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSPLSKNLYHRAISES 282

  Fly   236 GSA--TNHFDIDNLFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNY 298
            |..  |..|..|.....:::|...||.......:|.|||.:|...::|:.:.....:|.:.:...
  Rat   283 GVVLITELFTKDVRPAAKQIADMAGCKTTTSAIIVHCLRQKTEEELLEIMEKMNLIKLSSQRDTK 347

  Fly   299 E--------IDGHFLHNHPTELIKEGNFNKVPLLISFTANEFDY---------NANVHLENQ--- 343
            |        ||...|...|.|::.|.|||.||.::.....|..:         ..:|.|:.:
  Rat   348 ESYHFLSTVIDDVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMRFVPPDVKLDKKMAI 412

  Fly   344 HLLHDFASNF---VDYAP-ELFLYRHDAQIGEKLKDFYLGDNTTEINSENIENFGQIFSDAYIGH 404
            .||..|||.:   .|..| .:..||..:....|::|..|                     |:||.
  Rat   413 MLLEKFASIYGIPEDIIPVAIEKYRKGSDDPIKIRDGIL---------------------AFIGD 456

  Fly   405 GV-----------HRLVQLASHFTPVYYTRMDYVGDQSLSAPLNGENKPVGV--GHADDLHYVLP 456
            .:           ||     ....|.|.....|.  .|.|:|    .:|..|  .||||::.|
  Rat   457 ALFCIPSVMVSRDHR-----DAGAPTYVYEYQYY--PSFSSP----QRPKDVVGDHADDVYSV-- 508

  Fly   457 GYWYG-PLM--AANDSDVFMMERLTSWFTHFAKTGTPLNSTDI--WPPCNSTVLKMLYNGVVTQV 516
               :| |::  .|::.::.:.:.:..::.:||:.|.| |...:  ||..:... :.|..|..||.
  Rat   509 ---FGAPILRDGASEEEIKLSKMVMKFWANFARNGNP-NGRGLPHWPQYDQKE-EYLQIGATTQQ 568

  Fly   517 GSPGYSNRYAVWDKL 531
            .....:...|.|.:|
  Rat   569 SQGLKAEEVAFWTQL 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	168/567 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	61/118 (52%)
Cesl1	XP_038953870.1	COesterase	57..580	CDD:395084	168/564 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.050