DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and CG4757

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	192/553 - (34%)
Similarity:	300/553 - (54%)	Gaps:	41/553 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLILIGFTTAVTFIGDDPVVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPET 76
            ||:|:..::.::.     .|:..|||::|..:.|......:||||||||:.|:|.|||.||.|..
  Fly     9 LLVLLASSSVLSI-----EVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVK 68

  Fly    77 SWGDEVFNATSDSLVCPQP-GVVSLMSEDCLKINVFTKSFEDKFPVMVYIHGGANVLGSGHSSYE 140
            .|..::|:|:.|..:|||| ..::.:|||||::||:||..:.:.||:|::|.|...:.||.|.|.
  Fly    69 PWSPKIFDASEDGPMCPQPWDNMTDVSEDCLRLNVYTKDLKGRRPVIVFLHPGGFYVFSGQSKYL 133

  Fly   141 AGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTI 205
            |||::.:|:|.|.|:.|||||:||||:|.|.|..||.|..|||:||.|::.||..|||||:.||:
  Fly   134 AGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTL 198

  Fly   206 IGISAGSMAVSLHLASPLSAGLFHRAILMSGSATN--HFDIDNLFWTRKLARELGCPMYDPTDVV 268
            :|.||||::|:||:.||:|.|||||.|.||.:...  .:..::|...::.|..|.||.....::|
  Fly   199 LGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMV 263

  Fly   269 ECLRNETWTRIVEVCKAWETYQ-LVNMKWNYEID-----------GHFLHNHPTELIKEGNFNKV 321
            ||:|.:.:...|      .||. :....||..::           ..:|...|.:..:.|:|:||
  Fly   264 ECMRRKPYLDYV------STYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKV 322

  Fly   322 PLLISFTANEFDYNANVHLENQHLLHDFASNFVDYAP-ELFLYRHDAQ---IGEKLKDFYLGDNT 382
            .|:...|..||...|...|.|:.:::.:..::..||. .|.|.::..|   .....::.|:.::.
  Fly   323 ALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESL 387

  Fly   383 TEIN-SENIENFGQIFSDAYIGHGVHRLVQLASHFTPVYYTRMDYVGDQS-LSAPLNGENKPVGV 445
            .::. .::::..|::.|||.||...||.:||.|..||:|.....|.|..: |..|.|  .:.:|.
  Fly   388 DKLEYPKSLKGMGELLSDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDN--QQTIGP 450

  Fly   446 GHADDLHYVLPGYWYGPLMAANDSDVFMMERLTSWFTHFAKTGTPLNSTD------IWPPCNSTV 504
            .|.|:|.|:.......||:...|.:.||:|.||..:..||:.|.|.|..|      .||..|:..
  Fly   451 VHHDELIYLFHVGLLIPLLKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQD 515

  Fly   505 LKMLYNGVVTQVGSPG-YSNRYAVWDKLFPTAA 536
            ...|..|......|.| :.|||.:|:.|||.::
  Fly   516 KGYLEIGNNLTAKSGGFFLNRYQIWEDLFPLSS 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	185/528 (35%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	63/118 (53%)
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	185/537 (34%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	81/163 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467332
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3697
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25788
OrthoDB	1	1.010	-	-		D102505at50557
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.810