DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and Nlg1

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	161/588 - (27%)
Similarity:	261/588 - (44%)	Gaps:	115/588 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VELSLGRIQGDTMQ---SFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSW-GDEVFNATSDSLV 91
            :::..||:.|.|.:   :.|.:.:..|.|:.||::|.|..||..|.....| |.::  |.....|
  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKI--ARHLPPV 220

  Fly    92 CPQ--PGV----------------------VSLMSEDCLKINVFT-----KSFEDKFPVMVYIHG 127
            |||  |.:                      :...|||||.:|::.     :|...::.|:||:||
  Fly   221 CPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHG 285

  Fly   128 GANVLGSGH-------SSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTN-SSETKGNFGFLDQVM 184
            .:....||:       |||         .:|:.|..|||||.||||..: .:....|:..|||:.
  Fly   286 ESFEWNSGNPYDGSVLSSY---------GEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIA 341

  Fly   185 ALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDIDN--L 247
            ||.|::::|..||||...||::|.|.|:..|:..:.||:::|||||||||||||.:.:...|  |
  Fly   342 ALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSL 406

  Fly   248 FWTRKLARELGCPMYDPTD------VVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLH 306
            ..|.::|..|.||:.:..:      :::|||:..:..|:.:..|...:   :......:|||.:.
  Fly   407 QLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQF---STSLGPIVDGHVIP 468

  Fly   307 NHPTELIKE--GNFNKVPLLISFTANEFDYNANVHL---------ENQHLLHDFASNFVDYAPEL 360
            |.|.:::..  .:|::..||...|.:| .|:....|         |..:||..:..:..|..|:|
  Fly   469 NQPYKVMGHYTEHFSRYDLLFGITESE-SYHTLAALALEEGLRENERDNLLRFYMQSRFDIRPDL 532

  Fly   361 FLYRHDAQIGEKLKDFYLGDNTTEINSENIENFG---QIFSDAYIGHGVHRLVQLASHFTPVYYT 422
            .|    |...:|.:|.|    ...|.:.|:|:..   .|.|||.:   |..|:|.......|...
  Fly   533 AL----AATLKKYQDMY----NNPIKATNLEHRDVVLDILSDARV---VGPLLQTGMFHADVNRR 586

  Fly   423 RMDYV-GDQSLSAPLNGENKPVGVGHADDLHYVL--PGYWYGPLMAANDS--DVFMMERLTSWFT 482
            ...|| |..|.:.|.  .:.|..: ..::|.::.  |....||..:.|.:  :..:.|.:.:::|
  Fly   587 NYMYVFGHNSATGPF--AHLPHSI-MGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWT 648

  Fly   483 HFAKTGTP--------LNSTDI--------WPPCNSTVLKMLYNGVVTQVGSPGYSNRYA-VWDK 530
            :|.|||.|        :||..:        ||..|......|..|:...||.. |...|. .|:|
  Fly   649 NFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYK-YRQIYMNFWNK 712

  Fly   531 LFP 533
            ..|
  Fly   713 ELP 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	158/581 (27%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	49/126 (39%)
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	158/581 (27%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	57/153 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.810