DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and alpha-Est3

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001163540.1	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	161/544 - (29%)
Similarity:	241/544 - (44%)	Gaps:	117/544 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PVVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVCP 93
            ||:......:.||...|        |..|.|||.|||.|||..|:|...|        |..|.|.
  Fly    12 PVLGKQCTGVYGDEYVS--------FERIPYAQPPVGHLRFMAPLPVEPW--------SQPLDCT 60

  Fly    94 QPGVVSLM----------SEDCLKINVFTKSFED--KFPVMVYIHGGANVLGSG----HSSYEAG 142
            :||...|.          .||||.:||:.|..:.  ..|::|:..||....|..    ||
  Fly    61 KPGQKPLQFNHYSKQLEGVEDCLYLNVYAKELDSPRPLPLIVFFFGGGFEKGDPTKELHS----- 120

  Fly   143 PQYLLDQDVVFVAFNYRLGALGFLSTNSSE--TKGNFGFLDQVMALEWVRDHISHFGGDPELVTI 205
            |.|.:.:|||.|..:||:|.|||||.|...  ..||.|..||::|:||::::...|.|||:.||.
  Fly   121 PDYFMMRDVVVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTA 185

  Fly   206 IGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHF---DIDNLFWTRKLARELGCPMYD-PTD 266
            .|.|||:.:|...:.:|.:.||||:|||.||:....:   .|.||  ..:||..||....: .||
  Fly   186 FGESAGAASVHYLMLNPKAEGLFHKAILQSGNVLCSWALCTIKNL--PHRLAVNLGMESAEHVTD 248

  Fly   267 --VVECLRNETWTRIVE--VCKAWE-----TYQLVNMKWNYEIDGHFLHNHPTELIKEGNFNKVP 322
              |::.|:.....::|.  :..|.|     .:|...|...|:.:...|.|||.||:.:...|::|
  Fly   249 AMVLDFLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIP 313

  Fly   323 LLISFTANE--FDYNANVHL----------ENQHLLH-DFASNFVDYAPELFLYRHDAQIGEKLK 374
            :|:|.|:.|  ..| |.|.:          |.:|:|. |...|.    |:. |.||   :|::|:
  Fly   314 VLMSGTSFEGLLMY-ARVQMAPYLLTSLKKEPEHMLPLDVKRNL----PQA-LARH---LGQRLQ 369

  Fly   375 DFYLGDN-TTEINSENIENFGQIFSDAYIGHGVHRL----VQLASHFTPVY----------YTRM 424
            :.:.|.| .:.::.|:::.:.:..|.....|.:.:.    |:.:|..|.:|          :.|:
  Fly   370 ETHFGGNDPSAMSPESLKAYCEYASYKVFWHPILKTLRSRVKSSSASTYLYRFDFDSPTFNHQRL 434

  Fly   425 DYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPL---MAANDSDVFMMERLTSWFTHFAK 486
            .|.||           |..||.|.||..|:    |||..   :..:..:...:||:....|.||:
  Fly   435 KYCGD-----------KLRGVAHVDDHSYL----WYGDFSWKLDKHTPEFLTIERMIDMLTSFAR 484

  Fly   487 TGTP--------LNSTDIWPPCNS 502
            |..|        |.....|.|.||
  Fly   485 TSNPNCKLIQDQLPRAKEWKPLNS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	161/544 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	49/126 (39%)
alpha-Est3	NP_001163540.1	Abhydrolase	3..529	CDD:304388	161/544 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467402
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.890