DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and alpha-Est10

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	161/562 - (28%)
Similarity:	241/562 - (42%)	Gaps:	94/562 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVCPQ 94
            |::...|.::|....:....:.::|..|.:|:.|||.|||..|.....|..|        |.|..
  Fly    50 VIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQE--------LDCTS 106

  Fly    95 PGVVSLM----------SEDCLKINVFTKSFE-DKF-PVMVYIHGGANVLG-SGHSSYEAGPQYL 146
            |....|.          |||||.:||:.|..: ||. ||||:|:||...:| :....|  .|.:.
  Fly   107 PADKPLQTHMFFRKYAGSEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASRDMY--SPDFF 169

  Fly   147 LDQDVVFVAFNYRLGALGFLSTNSSE--TKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGIS 209
            :.:|||.|...||||||||||.:..:  ..||.|..||:|||.||:.:|..||||...:|:.|.|
  Fly   170 MSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGES 234

  Fly   210 AGSMAVSLHLASPLSAGLFHRAILMSGSA--------TNHFDIDNLFWTRKLARELGCPMY--DP 264
            ||..:......||.:.||.|:||:||||.        .|:       |..:||::||   |  |.
  Fly   235 AGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNN-------WAYRLAQKLG---YTGDN 289

  Fly   265 TD--VVECLRNETWTRIVEVCKAWETYQLVNMKWN------------YEIDGHFLHNHPTELIKE 315
            .|  :.|.||:.:...||   ||..|....:.|.:            |..:...:...|.||::.
  Fly   290 KDKAIFEFLRSMSGGEIV---KATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQN 351

  Fly   316 GNFNKVPLLISFTANE--FDYNANVHLENQHLLHDFASNFVDYAPELFLYRHDAQI----GEKLK 374
            ...:::|::...|:.|  ..|   ..:..:....|...|..:..|.......|.::    |.:||
  Fly   352 SWSHRIPMMFGGTSFEGLLFY---PEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLK 413

  Fly   375 DFYLGDNTTEINSENIENFGQIFSDAYIGHGVHR--LVQLASHFTPVYYTRMDYVGDQSLSAPLN 437
            ..|.||.  ..|..|:..|.::.|.....|.::|  |.::.....|.|..|.|:  |..|...:.
  Fly   414 KAYFGDE--PCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDH--DSKLCNAIR 474

  Fly   438 ----GENKPVGVGHADDLHYVLPGYWYGPL--MAANDS-DVFMMERLTSWFTHFAKTGTP----L 491
                | ::..||.|.|||.|:    ::..|  .:|.|| :..::..:...:|.||..|.|    :
  Fly   475 IVLCG-HQMRGVCHGDDLCYI----FHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPNCESI 534

  Fly   492 NSTDIWPPCNSTVLKMLYNGVVTQV-GSPGYSNRYAVWDKLF 532
            .|....|..|.|..|.|..|...:| ..|.......||:..:
  Fly   535 KSLKFAPIENVTNFKCLNIGDQFEVMALPELQKIEPVWNSFY 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	159/556 (29%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	53/123 (43%)
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	151/526 (29%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	61/155 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467420
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40835at6656
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.850