Protein Alignment CG3841 and AADACL2

DIOPT Version :10

• Sequence 1: NP_609300.1
• Gene: CG3841 / 34278
• FlyBaseID: FBgn0032131
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_997248.2
• Gene: AADACL2 / 344752
• HGNCID: 24427
• Length: 401
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 88/459 - (19%)
• Similarity: 152/459 - (33%)
• Gaps: 131/459 - (28%)

  Fly     1 MPRFFQLTWALLLILIGFTTAVTFIGDDPVVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQ--SP 63
            ||...:.:|. ::.|.......||                 |...|.|..|     :||.:  |.
Human    23 MPDNIEESWK-IMALDAIAKTCTF-----------------TAMCFENMRI-----MRYEEFISM 64

  Fly    64 VGQLRFANPVPETSWGDEVFNATSDSLVCPQPGVVSLMSEDCLKINVFTKSFEDKFPVMVYIHGG 128
            :.:|.:..|:     .||....|..:.|           :..:::.:..:..|.:...::|.|||
Human    65 IFRLDYTQPL-----SDEYITVTDTTFV-----------DIPVRLYLPKRKSETRRRAVIYFHGG 113

  Fly   129 ANVLGSGHSSYEAGPQYLLD---------QDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVM 184
            ....||       ..|...|         .|.|.|..:|||.........         |.|.:.
Human   114 GFCFGS-------SKQRAFDFLNRWTANTLDAVVVGVDYRLAPQHHFPAQ---------FEDGLA 162

  Fly   185 ALEW--VRDHISHFGGDPELVTIIG-ISAGSMAVSLHLASPLSAGLFHR---------------A 231
            |:::  :...::.:|.||..:.|.| .|.|::|.::.......|.:.|:               :
Human   163 AVKFFLLEKILTKYGVDPTRICIAGDSSGGNLATAVTQQVQNDAEIKHKIKMQVLLYPGLQITDS 227

  Fly   232 ILMSGSATNHFDIDNLFWTRKLARELGCPMYDPTDVVECL-----RNETWTRIVEVCKAWETYQL 291
            .|.|.....|    .:..||.:|.:| ..:|...|  |.|     ||:...     .::...::.
Human   228 YLPSHRENEH----GIVLTRDVAIKL-VSLYFTKD--EALPWAMRRNQHMP-----LESRHLFKF 280

  Fly   292 VNMKWNYEIDGHFLHNHP-TELIKEGNFNKVPLLISFTANEFDYNANVHLENQHLLHDFASNFVD 355
            ||  |:..:...:..::. ||.|..|....:|.|.       |..|...|.|...|.:....::
Human   281 VN--WSILLPEKYRKDYVYTEPILGGLSYSLPGLT-------DSRALPLLANDSQLQNLPLTYI- 335

  Fly   356 YAPELFLYRHDAQIGEKLKDFYLGDNTTEINSENIENFGQIFSDAYIGHGVHRLVQLASHFTPVY 420
                 ...:||.     |:|    |....:.  .:.|.|......:|..|:|..:   |..|..:
Human   336 -----LTCQHDL-----LRD----DGLMYVT--RLRNVGVQVVHEHIEDGIHGAL---SFMTSPF 381

  Fly   421 YTRM 424
            |.|:
Human   382 YLRL 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_609300.1	COesterase	27..528	CDD:395084	82/433 (19%)
AADACL2	NP_997248.2	Abhydrolase_3	107..372	CDD:400284	63/318 (20%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)