Protein Alignment CG3841 and AADACL4

DIOPT Version :10

• Sequence 1: NP_609300.1
• Gene: CG3841 / 34278
• FlyBaseID: FBgn0032131
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001013652.1
• Gene: AADACL4 / 343066
• HGNCID: 32038
• Length: 407
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 63/302 - (20%)
• Similarity: 96/302 - (31%)
• Gaps: 102/302 - (33%)

  Fly   122 MVYIHGGANVLGSGHSSYEAGPQYLL-DQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMA 185
            :::.||||.|.|| ...|.....||. :.:.|.:...||.     |..:.|...    |.|.:.|
Human   115 IIFYHGGATVFGS-LDCYHGLCNYLARETESVLLMIGYRK-----LPDHHSPAL----FQDCMNA 169

  Fly   186 LEWVRDHISHFGGDPELVTIIGISAGSMAVS-----------------------------LHLAS 221
            .......:..:|.||..|.:.|.|.|..||:                             |.|.|
Human   170 SIHFLKALETYGVDPSRVVVCGESVGGAAVAAITQALVGRSDLPRIRAQVLIYPVVQAFCLQLPS 234

  Fly   222 -------PLSAGLFHRAILMSGSATNHFDIDNLFWTRKLARELGCPMYDPTDVV---ECLRNETW 276
                   ||.:..|     |..|..|:..|| |.|               .|.:   .|:..:.|
Human   235 FQQNQNVPLLSRKF-----MVTSLCNYLAID-LSW---------------RDAILNGTCVPPDVW 278

  Fly   277 TRIVEVCKAWETYQLVNMKWNYEIDGHFLHNHPTELIKEGNFNKVPLLISFTANEFDYNANVHLE 341
            .:.    :.|.:...:..|:.         |...:....|.||:...|        :....:.:|
Human   279 RKY----EKWLSPDNIPKKFK---------NRGYQPWSPGPFNEAAYL--------EAKHMLDVE 322

  Fly   342 NQHLLHDFASNFVDYAPELFL-------YRHDAQIGEK-LKD 375
            |..|:.|  ...:...||.||       .|.|:.:.:| |:|
Human   323 NSPLIAD--DEVIAQLPEAFLVSCENDILRDDSLLYKKRLED 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_609300.1	COesterase	27..528	CDD:395084	63/302 (21%)
AADACL4	NP_001013652.1	alpha/beta hydrolases	115..378	CDD:473884	63/302 (21%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	119..121		1/1 (100%)