DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and CG6414

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	170/561 - (30%)
Similarity:	251/561 - (44%)	Gaps:	89/561 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVCPQ-----P 95
            |.:.|..:.:...:.:.||.|:.||:.|:..|||..|||:..|..|.. |..|:.:|.|     .
  Fly    38 GWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERL-AIKDAPICLQRDPFRR 101

  Fly    96 GVVSLMSEDCLKINVFTKS---FEDKFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFN 157
            .::...|||||.:||:|..   .....||||:.|||....|||.||: .||.:|||.|:|.|:.|
  Fly   102 DMILEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSF-YGPDFLLDHDIVLVSAN 165

  Fly   158 YRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASP 222
            :|||.||||||.:.:..||.|..||:..|.|||.:|:.|||||..||:.|.|||..:|:.|:.|.
  Fly   166 FRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSE 230

  Fly   223 LSAGLFHRAILMSGSATNHFDIDNLFWTR------------KLARELGC------PMYDPTDVVE 269
            .|.||.||.|..||:..|.       |.:            |||:.:||      |     :.:|
  Fly   231 KSRGLLHRGIAQSGTYFNP-------WAQPAHKGVAAGRATKLAQIVGCGNAGEWP-----EKLE 283

  Fly   270 CLRNETWTRIVEVCKAWETYQLVNMKWNY------------EIDGHFLHNHPTELIKEGNFNKVP 322
            |||.:....||.     ..|.:  ..|::            |.||.||...|.:..|.... ::|
  Fly   284 CLRKKPAEDIVA-----SLYDM--FVWDFDPMIPFPPVVEPEHDGAFLTVAPRQAAKPHGL-QLP 340

  Fly   323 LLISFTANEFDYNANVHLENQHLLHDFASNFVDYAPELFLYRHD-----AQIGEKLKDFYL--GD 380
            |::..||.|........|....||.:|.|.|....|.:..|.|.     ..|.::::.||.  |.
  Fly   341 LMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGH 405

  Fly   381 NTTEINSENIENFGQIFSDAYIGHGVHRLVQL---ASHFTPVYYTRMDYVGDQSLSAPL-NGENK 441
            :..:.|.:|:.:   :.||.:...|:...::|   .....|.|....|:.|..|.:... .|.|:
  Fly   406 DYDKANHQNLTD---LISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNE 467

  Fly   442 PVGVGHADDLHYVLP-GYWYGPLMAANDSDVFMMERLTSWFTHFAKTGTPLNSTDI------WPP 499
            ..|..||::|.|:.| |............|:.:.|.:...:..|||||.| |.|::      |.|
  Fly   468 FYGACHAEELQYLFPIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNP-NPTNVSFHLPNWSP 531

  Fly   500 CNSTVL-------KMLYNGVVTQVGSPGYSNRYAVWDKLFP 533
            .:|..:       ||..:..:.::.:....:|...|..|.|
  Fly   532 ASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRDLQP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	167/554 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	60/118 (51%)
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	167/554 (30%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	66/145 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102505at50557
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870