DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and Ces5a

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	618	Identity:	175/618 - (28%)
Similarity:	273/618 - (44%)	Gaps:	140/618 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTWALLLILIGFTTAVTFIGDDPVVELSLGRIQGDTMQSFGN-KTIYAFRGIRYAQSPVGQLRFA 70
            |.|.|.:.......:||   ::|.....||.:||......|. :.:..|.||.:|..|:|.|||:
  Rat    12 LIWVLWIFAAIIRGSVT---EEPHRYTRLGWVQGKQATVLGRLEPVNVFLGIPFAAPPLGPLRFS 73

  Fly    71 NPVPETSWGDEVFNATSDSLVC------------------PQPGVVSLMSEDCLKINVFTKSFED 117
            ||.|...|.| :..||:...||                  |:.||    |||||.:|::..::.:
  Rat    74 NPQPPIPWHD-LREATTYPNVCFQNLEWLFIYQNLLKVHYPKLGV----SEDCLYLNIYAPAYAN 133

  Fly   118 ---KFPVMVYIHGGANVLGSGHSSYEAGPQYLLD-------QDVVFVAFNYRLGALGFLSTNSSE 172
               :.|||::|.||         .:|.|...:.|       :||:.|...||||..||.:|.:..
  Rat   134 DGSRLPVMMWIPGG---------GFETGSASIFDGSALAAYEDVLIVTIQYRLGIFGFFNTQNQH 189

  Fly   173 TKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGS 237
            ..||:.|.||:.||:|||::|::|||:|:.|||.|.|||::::|..:.||||||||||||:.||.
  Rat   190 APGNWAFQDQLAALQWVRENINYFGGNPDSVTIFGGSAGAISISSLILSPLSAGLFHRAIMQSGV 254

  Fly   238 A----TNHFDIDNLFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNY 298
            |    ..:||.:.....:.:|....|.:.|...:::|||.::...::.:.:..:.:..|
  Rat   255 AIIPSLKNFDDELKHGLQVVADVCKCNVSDSKVLLKCLREKSSLELLSLGQKTKAFTRV------ 313

  Fly   299 EIDGHFLHNHPTELIKEGNFNKVPLLISFTANEFDY--------------NANVHLENQH-LLHD 348
             :||.|....|.||:.:..|..||.:|.....|..|              |.:..|...| |||
  Rat   314 -VDGSFFPEEPMELLSQKTFKTVPSIIGVNNQECGYILPMREAPEILFGSNESTALTLIHVLLH- 376

  Fly   349 FASNFVDYAPELFLYRHDAQIGEKLKDFYLGDNT-TEINSENIENFGQIFSDAYIGHGVHRLVQL 412
                   ..|:   |.|..     .||::.|.:: |:|....::.||.:|   ::..|   ||..
  Rat   377 -------IPPQ---YMHIV-----AKDYFHGKHSLTDIRDTLLDLFGDVF---FVVPG---LVTA 420

  Fly   413 ASHFT---PVYYTRMDYVGDQSLSAPLNGEN-KP--VGVGHADDLHYVLPGYWYGPLMAANDSDV 471
            .:|..   |||:....:       .|...:| :|  |...|.|::.:|    :.||.:   :.||
  Rat   421 RNHRDAGGPVYFYEFQH-------RPNCFQNTRPAFVKADHTDEIRFV----FGGPFL---EGDV 471

  Fly   472 FMMERLT-----------SWFTHFAKTGTPLNSTD--IWPPC--NSTVLKMLYNGVVTQVGSPGY 521
            .|.|..|           |::.:||::|.| |..|  :||..  |.:.||:..|      .|.|:
  Rat   472 VMFEEATEDEKLLSRKMMSYWANFARSGDP-NGDDLPLWPAYDQNESYLKLDVN------ISTGW 529

  Fly   522 ---SNRYAVWDKLFPTAAQGGGAALKLSFAVAI 551
               ..|...|....|.......|.|..:|.:.:
  Rat   530 RLKDRRVEFWTDTLPLITSASKALLSPTFPLIL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	165/573 (29%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	54/128 (42%)
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	160/552 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336110
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.800