DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and Ces2i

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_008758816.2	Gene:	Ces2i / 292152	RGDID:	1565045	Length:	558	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	168/569 - (29%)
Similarity:	267/569 - (46%)	Gaps:	71/569 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WALLLILIGFTTAVTFI-GDD---PVVELSLGRIQGDTMQSFGNKT-IYAFRGIRYAQSPVGQLR 68
            | |.::..|....:..: |.|   |:.....|:::|..:.....|: ::.|.||.:|:.|||.|.
  Rat     9 W-LYVVACGLLLLLQHVHGQDSASPIRNTQTGQVRGSFVHVKDTKSGVHTFLGIPFAKPPVGPLH 72

  Fly    69 FANPVPETSWGDEVFNATSDSLVCPQPGVV--------------SLMSEDCLKINVFTKSFE--- 116
            ||.|.....|.. |.:.||...:|.|..::              :.||||||.:|::|.:..
  Rat    73 FAPPEDPEPWSG-VRDGTSQPDMCLQTDIMKEDFIKEMKLTMHPTPMSEDCLYLNIYTPAHAREG 136

  Fly   117 DKFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLD 181
            ...||||:||||..||||  :|..........:::|.||..||||.|||.||.....:||:|:||
  Rat   137 SNLPVMVWIHGGGLVLGS--ASMNVASTLAATEEIVIVAIQYRLGILGFFSTGDEHARGNWGYLD 199

  Fly   182 QVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNH---FD 243
            ||.||.||:.:|::|||:...|||.|:|||..:||.|:.||:|.||||.||:.||.|...   .|
  Rat   200 QVAALCWVQQNIAYFGGNHGKVTIFGVSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLPDLISD 264

  Fly   244 IDNLFWTRKLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNH 308
            ...:.: :.:|...||...|...::.|||.::...|:.:.:.::....|       :||.||..|
  Rat   265 TSEVVY-KTVANLSGCEASDSEALIRCLRAKSKQEILAINQVFKMIPGV-------VDGKFLPKH 321

  Fly   309 PTELIKEGNFNKVPLLISFTANEFDYNANVHLENQHLLHDFASNFV-----DYAPELFLYRHDAQ 368
            |.||:..|:|:.||.:|....:|......:.:...|::.....:.:     ..|.::.|   ..:
  Rat   322 PQELLASGDFHPVPSIIGVNTDECGLGVPMFMGLDHIIKKITRDTLPTVLKSTAAQMML---PPE 383

  Fly   369 IGEKLKDFYLGDNTTEINSENIENFGQIFSDAYIGHGVHRLVQLASHF----TPVYYTRMDYVGD 429
            ..:.:.:.|:||  ||......|.|.::..|...   |...:::| ||    .|||:...
  Rat   384 CIDLIMEEYMGD--TEDPETLQEQFKEMLGDFMF---VIPALEVA-HFQRSQAPVYFYEF----- 437

  Fly   430 QSLSAPLNGENKP--VGVGHADDLHYVLPGYWYGPLMAANDSDVFMMERLTSWFTHFAKTGTPLN 492
            |.|.:.:. :.:|  |...|.||:.:|...|::|......:.:..:..|:..::.:||:.|.| |
  Rat   438 QHLPSFIK-QVRPSHVKADHGDDILFVFSSYFWGMNFDITEEEELLKRRVMKYWANFARNGNP-N 500

  Fly   493 STDI--WPPCNSTVLKMLYNGVVTQ--VGSPGYSNRYAVWDKLFPTAAQ 537
            |.|:  ||..:.....:..|   ||  ||....:.|...|.|..|...|
  Rat   501 SEDLPYWPVLDHNEQYLQLN---TQPAVGRALKARRLQFWTKTLPQKIQ 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	160/539 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	59/121 (49%)
Ces2i	XP_008758816.2	COesterase	30..537	CDD:395084	159/536 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336232
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900