Protein Alignment CG3841 and CES4A

DIOPT Version :9

• Sequence 1: NP_001188759.1
• Gene: CG3841 / 34278
• FlyBaseID: FBgn0032131
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 172/615 - (27%)
• Similarity: 268/615 - (43%)
• Gaps: 114/615 - (18%)

  Fly     7 LTWALLLILIGFTTAVTFIGDDPVVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFAN 71
            |.|:|.|.|:..|.........|.|....|.:||..|. .|...|..|.|:.:::.|:|.||||.
Human    28 LCWSLTLCLMAQTALGALHTKRPQVVTKYGTLQGKQMH-VGKTPIQVFLGVPFSRPPLGILRFAP 91

  Fly    72 PVPETSW------------------------GDEVFNATSDSLV----CPQP------------- 95
            |.|...|                        ......|||.|.|    .|||
Human    92 PEPPEPWKGIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESW 156

  Fly    96 GVVSLM-------------SEDCLKINVFTKS---FEDKFPVMVYIHGGANVLGSGHSSYEAGPQ 144
            |.::.|             |||||.:||:..:   .:.:.||||:..|||.::|:. |||| |..
Human   157 GQLASMYVSTRERYKWLRFSEDCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAA-SSYE-GSD 219

  Fly   145 YLLDQDVVFVAFNYRLGALGFL----STNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTI 205
            ....:.||.|...:|||..|||    .|:.|..:||:|.|||:.||.||:::|:.|||||..||:
Human   220 LAAREKVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTL 284

  Fly   206 IGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDIDNLFWT-------RKLARELGCPMYD 263
            .|.|||:|::|..:.|||::|||||||..||:|     :..||.|       :|:|...||....
Human   285 FGQSAGAMSISGLMMSPLASGLFHRAISQSGTA-----LFRLFITSNPLKVAKKVAHLAGCNHNS 344

  Fly   264 PTDVVECLRNETWTRIVEVCKAWETYQLVNMK-------WNYE--IDGHFLHNHPTELIKEGNFN 319
            ...:|.|||..:.|:::.|.......|| |.:       |:..  :||..:.:.|..|:.:|..:
Human   345 TQILVNCLRALSGTKVMRVSNKMRFLQL-NFQRDPEEIIWSMSPVVDGVVIPDDPLVLLTQGKVS 408

  Fly   320 KVPLLISFTANEFD----YNANVHLENQHLLHDFASNFVDYAPELFLYRHDAQIGEKLKDFYLGD 380
            .||.|:.....||:    |.....|..|.:..:..:..: ::....|.....|:...::::.  |
Human   409 SVPYLLGVNNLEFNWLLPYIMKFPLNRQAMRKETITKML-WSTRTLLNITKEQVPLVVEEYL--D 470

  Fly   381 NTTEINSENIEN-FGQIFSDAYIGHGVHRLVQLASHF-----TPVYYTRMDYVGDQSLSAPLNGE 439
            |..|.:.:.:.| ...|..||..   |:..:|.| |:     .|||....::.....:..|
Human   471 NVNEHDWKMLRNRMMDIVQDATF---VYATLQTA-HYHRDAGLPVYLYEFEHHARGIIVKP---- 527

  Fly   440 NKPVGVGHADDLHYVLPGYWYGPLMAANDSDVFMMERLTSWFTHFAKTGTPLNSTDI--WPPCNS 502
             :..|..|.|:::::..|.:...|....:..:.:  ::..::.:||:||.| |..::  ||..|.
Human   528 -RTDGADHGDEMYFLFGGPFATGLSMGKEKALSL--QMMKYWANFARTGNP-NDGNLPCWPRYNK 588

  Fly   503 TVLKMLYNGVVTQVGSPGYSNRYAVWDKLF 532
            .. |.|.....|:||......:.|.|..|:
Human   589 DE-KYLQLDFTTRVGMKLKEKKMAFWMSLY 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	164/589 (28%)
		Aes	<116..>235	CDD:223730	58/122 (48%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	164/591 (28%)
		Aes	<184..>291	CDD:223730	46/108 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142746
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740