DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3841 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	176/573 - (30%)
Similarity:	270/573 - (47%)	Gaps:	79/573 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WALLLILIGFTTAVTFI-GDD---PVVELSLGRIQGDTMQSFGNKT-IYAFRGIRYAQSPVGQLR 68
            | |.::..|....:..: |.|   |:.....|:::|..:.....|: |:.|.||.:|:.|||.||
  Rat     9 W-LYVVACGLLLLLQHVHGQDSASPIRNTHTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVGPLR 72

  Fly    69 FANPVPETSWGDEVFNATSDSLVCPQPGVVSL--------------MSEDCLKINVFTKSFE--- 116
            ||.|.....|.. |.:|||...:|.|..:::|              ||||||.:|::|.:..
  Rat    73 FAPPEDPEPWSG-VRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREG 136

  Fly   117 DKFPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLD 181
            ...||||:||||..||||  :|..........:::|.|:..||||.|||.||.....:||:|:||
  Rat   137 SNLPVMVWIHGGGLVLGS--ASMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQNARGNWGYLD 199

  Fly   182 QVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDIDN 246
            ||.||.||:.:|::|||:...|||.|.|||..:||.|:.||:|.||||.||:.||.|.    :.:
  Rat   200 QVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVAL----LPD 260

  Fly   247 LFWTRK------LARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFL 305
            |...:.      :|...||...|...::.|||.::...|:.:.:.::....|       :||.||
  Rat   261 LISDKSEVVYKTVANLSGCEAPDSEALIRCLRAKSKQEILAINQVFKMIPGV-------VDGKFL 318

  Fly   306 HNHPTELIKEGNFNKVPLLISFTANEFDYNANVHLENQHLLHDFASNFV-----DYAPELFLYRH 365
            ..||.||:..|:|:.||.:|....:|..:...|.|...|::.......:     ..|.::.|
  Rat   319 PKHPQELLASGDFHPVPSIIGINTDECGWGIPVFLGLDHIIKKITRETLPTVLKSTAAQMML--- 380

  Fly   366 DAQIGEKLKDFYLGDNTTEINSENI-ENFGQIFSDAYIGHGVHRLVQLASHF----TPVYYTRMD 425
            ..:..:.:.:.|:||  || |.|.: |.|..:..|...   |...:|:| ||    .|||:...
  Rat   381 PPECIDLIMEEYMGD--TE-NPETLQEQFRHMLGDFMF---VIPALQVA-HFQRSQAPVYFYEF- 437

  Fly   426 YVGDQSLSAPLNGENKP--VGVGHADDLHYVLPGYWYGPLMAANDSDVFMMERLTSWFTHFAKTG 488
                |.|.:.:. :.:|  |...|.||:.:|...|.:|......:.:..:..|:..::.:||:||
  Rat   438 ----QHLPSFIK-QVRPSHVKADHGDDILFVFGSYLWGMTFDLTEEEELLKRRVMKYWANFARTG 497

  Fly   489 TPLNSTDI--WPPCNSTVLKMLYNGVVTQ--VGSPGYSNRYAVWDKLFPTAAQ 537
            .| |..|:  ||..:.....:..|   ||  ||....:.|...|.|..|...|
  Rat   498 NP-NGEDLPHWPVLDHDEQYLQLN---TQPAVGRALKARRLQFWTKTLPQKIQ 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	168/543 (31%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	58/121 (48%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	167/540 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336215
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900